Evidence map›Paper›PMID 39298551›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.

Aihua Wu, Yahua Zhang, Fabian Bock, Juan Pablo Arroyo, Eric Delpire, Ming-Zhi Zhang, Raymond C Harris, Andrew S Terker

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Potassium and the kidney.Nature reviews. Nephrology · 2026
    Review
  2. KiScience · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aihua WuDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Yahua ZhangDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Fabian BockDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-0788-2945
Juan Pablo ArroyoDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-5992-5011
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-3702-1599
Ming-Zhi ZhangDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Raymond C HarrisDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Andrew S TerkerDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-1498-9043

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
The Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1M
Innovative therapeutic approaches to treat chronic kidney diseaseDP5OD033412 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERKER, ANDREW S. · 2022 to 2025
$2.2M
Understanding the physiology and pathophysiology of kidney-derived vasopressinK08DK135931 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Juan Pablo Arroyo Ornelas · 2023 to 2026
$696k
Rac1 and the actin cytoskeleton in renal tubular repairK08DK134879 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Fabian Maximilian Bock · 2023 to 2026
$636k
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK093501HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK134879HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK135931HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK51265HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DP5OD033412NIDDK NIH HHS K08 DK134879NIDDK NIH HHS K08 DK135931NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK093501NIH HHS DP5 OD033412
6 · The paper itself

Abstract

Inadequate dietary potassium (K

Indexed as

KidneyMacrophagesMice, KnockoutProtein Serine-Threonine KinasesAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLNephritisPhosphorylationPotassium DeficiencyPotassium, DietaryWNK Lysine-Deficient Protein Kinase 1Potassium, DietaryProtein Serine-Threonine KinasesStk39 protein, mouseWnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1kidney injurymacrophagepotassiumSPAKWNK kinase

Identifiers

PMID39298551
PMCPMC11563591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.