SynthesisRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2024
The amygdala as a therapeutic target for aggressive and disruptive behaviors: a systematic review.
Synthesis in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Mental States of Aggressors: A Biopsychosocial Analysis of Workplace Violence Reports in Hospitals.American journal of industrial medicine · 2026Article
- Functional psychosurgery in psychiatry: indications and preoperative evaluation. A narrative review.Frontiers in psychiatry · 2026Review
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify the effects of amygdala neuromodulation on disruptive behavior and quality of life changes in patients and its relationship with epilepsy.
methodsThe MEDLINE, OVID, WoS, Central Cochrane, and Scopus databases were systematically searched up to March 2023 for studies with at least six months of follow-up on extremely aggressive patients who underwent ablative surgeries or deep brain stimulation of the amygdala as the unique therapeutic target.
resultsThe search yielded 1,352 studies after excluding duplicates. However, only 11 case series and three case reports met the inclusion criteria. The studies were published between 1963 and 2023 and included 1,033 patients, mostly male, aged between 5 and 61 years. All of the studies performed amygdalotomy except one, which performed deep brain stimulation. Behavior improved in > 70% of the patients, and seizures occurred in approximately 30%, of whom 40% presented improvement. Two studies reported worsening behavior.
conclusionsAlthough we found that amygdalotomy has a positive effect on patient behavior and seizure control, new studies with greater power are needed. Future studies should investigate deep brain stimulation and the role of connectomics regarding this brain structure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.