Evidence map›Paper›PMID 39298016›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses.

Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abdelrahim AlqudahDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan. Abdelrahim@hu.edu.jo.ORCID 0000-0003-3721-8225
Esam QnaisDepartment of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan.ORCID 0000-0002-6203-4527
Omar GammohDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.ORCID 0000-0001-8801-2652
Yousra BseisoDepartment of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan.ORCID 0000-0002-4346-5049
Mohammed WedyanDepartment of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan.ORCID 0000-0002-8693-5506

Funding

Hashemite University 30/2020
6 · The paper itself

Abstract

The escalating global burden of cardiovascular diseases is a growing concern. Numerous research studies have established that plant-derived polyphenols, including α-pinene-a monocyclic monoterpene found in various plant essential oils-have significant effects on key cardiovascular mechanisms. These effects are mediated through their influence on antioxidant systems, cellular signaling pathways, and gene transcription processes. This study investigated the protective effects of α-pinene against cardiac damage caused by carbon tetrachloride (CCl

Indexed as

AntioxidantsBicyclic MonoterpenesCardiotonic AgentsHeart DiseasesMonoterpenesAnimalsBiomarkersCarbon TetrachlorideDose-Response Relationship, DrugInflammationInflammation MediatorsLipid PeroxidationMaleOxidative StressRatsRats, Wistaralpha-pineneAntioxidantsBicyclic MonoterpenesBiomarkersCarbon TetrachlorideCardiotonic AgentsInflammation MediatorsMonoterpenesAntioxidant defenseCarbon tetrachloride (CCl4)Cardiac injuryInflammatory markersα-Pinene

Identifiers

PMID39298016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.