Evidence map›Paper›PMID 39297992›Full record

ArticleArchives of microbiology2024

Effects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm.

Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Baobao Liu, Yuxin Wang, Yang Wang

Abstract read
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In one paragraph

Article in Archives of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuji Gao *College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Shuo Yuan *College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Yingying QuanCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Wenjie JinCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Yamin ShenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Baobao LiuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Yuxin WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China. wangyuxin_1991@163.com.
Yang WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China. wangyocean@163.com.

Funding

Excellent Youth Foundation of Henan Scientific Committee 222300420005National Natural Science Foundation of China 32172852Program for Innovative Research Team (in Science and Technology) in University of Henan Province 24IRTSTHN033
6 · The paper itself

Abstract

Biofilm is the primary cause of persistent infections caused by Streptococcus suis (S. suis). Metabolism and AI-2 quorum sensing are intricately linked to S. suis biofilm formation. Although the role of the AI-2 quorum sensing luxS gene in S. suis biofilm has been reported, its specific regulatory mechanism remains unclear. This study explored the differences in biofilm formation and monosaccharide metabolism among the wild type (WT), luxS mutant (ΔluxS) and complement strain (CΔluxS), and Galleria mellonella larvae were used to access the effect of luxS gene deletion on the virulence of S. suis in different monosaccharide medias. The results indicated that deletion of the luxS gene further compromised the monosaccharide metabolism of S. suis, impacting its growth in media with fructose, galactose, rhamnose, and mannose as the sole carbon sources. However, no significant impact was observed in media with glucose and N-acetylglucosamine. This deletion also weakened EPS synthesis, thereby diminishing the biofilm formation capacity of S. suis. Additionally, the downregulation of adhesion gene expression due to luxS gene deletion was found to be independent of the monosaccharide medias of S. suis.

Indexed as

Bacterial ProteinsBiofilmsCarbon-Sulfur LyasesMonosaccharidesQuorum SensingStreptococcus suisAnimalsGene DeletionGene Expression Regulation, BacterialHomoserineLactonesLarvaVirulenceBacterial ProteinsCarbon-Sulfur LyasesHomoserineLactonesLuxS protein, BacteriaMonosaccharidesN-octanoylhomoserine lactoneBiofilmInfectionluxS geneStreptococcus suisSugar metabolism

Identifiers

PMID39297992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.