Evidence map›Paper›PMID 39297942›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2025

BMP10 reflects pre-capillary pulmonary hemodynamics: association of biomarkers and hemodynamic parameters in pulmonary hypertension.

Elisa Hennings, Stefanie Aeschbacher, Michael Coslovsky, Rebecca E Paladini, Gian Voellmin, Maurin Lampart, André Ziegler, Christian Müller, David Conen, Christine S Zuern and 3 more

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Elisa HenningsCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefanie AeschbacherCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Michael CoslovskyDepartment of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Rebecca E PaladiniCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Gian VoellminCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Maurin LampartCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
André ZieglerRoche Diagnostics International AG, Rotkreuz, Switzerland.
Christian MüllerCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Canada.
Christine S ZuernCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Michael KühneCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefan Osswald *Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Otmar Pfister *Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland. Otmar.Pfister@usb.ch.ORCID http://orcid.org/0000-0002-6155-5494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe role of biomarkers in diagnosing pulmonary hypertension (PH) and distinguishing between pre- and post-capillary PH remains poorly understood. We aimed to identify biomarkers with a strong association with mean pulmonary arterial pressure, mPAP (PH diagnosis) and pulmonary vascular resistance, PVR (pre-capillary component), but not with pulmonary arterial wedge pressure, PAWP (post-capillary component).

methodsBlood samples were collected in patients undergoing right heart catheterization within a prospective cross-sectional study. Biomarkers measured included BMP10, NT-proBNP, ANG2, ESM1/endocan, FGF23, GDF15, IGFBP7, IL6, MyBPC3, proC3, and proC6/endotrophin. Primary outcomes were mPAP, PVR, and PAWP, while secondary outcomes included PH diagnosis (mPAP > 20 mmHg) and elevated PVR (> 2 Wood units). Multivariable linear and logistic regression models were used to assess the relationship between biomarkers and outcomes.

resultsOf the 127 patients included (age 66 ± 13 years, 54% female), 73% were diagnosed with PH. BMP10, NT-proBNP, ANG2, MyBPC3, and FGF23 showed a strong association with mPAP (p < 0.001). BMP10 and NT-proBNP were strongly associated with PVR (p < 0.001), while NT-proBNP and ANG2 were strongly associated with PAWP (p < 0.001). NT-proBNP had the strongest association with the diagnosis of PH (area under the curve = 0.76). BMP10 was the only biomarker associated with elevated PVR (OR 1.60, 95%CI 1.01-2.54, p = 0.04) but not with PAWP (p = 0.86).

conclusionsSeveral biomarkers were strongly associated with mPAP, PAWP, and PVR. BMP10 was the only biomarker strongly associated with mPAP and PVR, but not with PAWP, thus reflecting the pre-capillary PH component. Measurement of BMP10 along with NT-proBNP may aid in diagnosing PH.

Indexed as

Bone Morphogenetic ProteinsHemodynamicsHypertension, PulmonaryPulmonary Wedge PressureVascular ResistanceAgedBiomarkersCardiac CatheterizationCross-Sectional StudiesFemaleFibroblast Growth Factor-23HumansMaleMiddle AgedPeptide FragmentsProspective StudiesBiomarkersBMP10 protein, humanBone Morphogenetic ProteinsFGF23 protein, humanFibroblast Growth Factor-23Peptide FragmentsBiomarkerBMP10NT-proBNPPulmonary hypertensionRight heart catheterization

Identifiers

PMID39297942
PMCPMC11839876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.