Evidence map›Paper›PMID 39297706›Full record

ReviewImmunotherapy2024

Bimekizumab for the treatment of hidradenitis suppurativa.

Rayad B Shams, Christopher J Sayed

Abstract readReview
In one paragraph

Review in Immunotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rayad B ShamsUniversity of North Carolina Chapel Hill School of Medicine, 321 S Columbia St, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2273-2301
Christopher J SayedUniversity of North Carolina Chapel Hill Department of Dermatology, 410 Market Street Suite 400A, Chapel Hill, NC 27516, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a painful, inflammatory dermatosis involving recurrent abscesses, nodules and tunnels in intertriginous regions. Biologics and other immunomodulators have significantly expanded the treatment options available for HS. Bimekizumab is a monoclonal antibody targeting both interleukin-17A and interleukin-17F, key mediators of inflammation, that is already approved for psoriasis, psoriatic arthritis and axial spondylarthritis. It is currently pending FDA review for HS treatment but has already received marketing authorization for this indication in Europe. This review aims to explore drug-specific characteristics of bimekizumab including its mechanism of action, pharmacokinetics and pharmacodynamics and the current state of the literature regarding its use in HS such as safety, efficacy and dosing, while highlighting its implications in clinical practice. Recent Phase II and III trial data demonstrating positive efficacy and safety profiles in the treatment of HS will also be detailed.

Indexed as

Antibodies, Monoclonal, HumanizedHidradenitis SuppurativaInterleukin-17HumansTreatment OutcomeAntibodies, Monoclonal, HumanizedbimekizumabIL17A protein, humanIL17F protein, humanInterleukin-17bimekizumabbiologicshidradenitis suppurativahidradenitis suppurativa treatmentimmunotherapyinflammatory dermatosesinterleukin-17pharmacokinetics

Identifiers

PMID39297706
PMCPMC11492705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.