SynthesisJournal of global health2024
Global prevalence of liver disease in human and domestic animals caused by Fasciola: A systematic review and meta-analysis.
Synthesis in Journal of global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prevalence and Associated Risk Factors of Bovine Fasciolosis in Injibara Town, North Western Ethiopia.Veterinary and animal science · 2026Article
- Prevalence of Fasciolosis and Dicrocoeliosis in Slaughtered Cattle and Sheep in Siirt Province, Türkiye: A Comparison of Coprological and Postmortem Findings.Veterinary sciences · 2026Article
- Development of a qPCR assay for Fasciola spp. identification and a deep amplicon sequencing method for differentiation of fluke species in UK livestock.PLoS neglected tropical diseases · 2026Article
- First Report of Fascioliasis of Ruminants in the Kharaa River Basin and Identification of Snail Hosts in Mongolia.Veterinary medicine international · 2026Article
- Pre-Existing Anti-Inflammatory Immune Conditions Influence Early Antibody Avidity and Isotype Profile Following ComirnatyVaccines · 2025Article
- Inverted Patterns of Schistosomiasis and Fascioliasis and Risk Factors Among Humans and Livestock in Northern Tanzania.Pathogens (Basel, Switzerland) · 2025Article
- Distinct gut microbiome features characterizeFrontiers in cellular and infection microbiology · 2025Article
- An overview of fasciolosis in human and cattle populations in New Valley, Egypt.Frontiers in veterinary science · 2025Article
- Harnessing mRNA technology againstFrontiers in immunology · 2025Article
- Characterization of the clinical features, laboratory findings, and outcomes of human fascioliasis in a global network: a retrospective mutlicenter study.Therapeutic advances in infectious diseaseArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Liver disease caused by Fasciola is a significant zoonotic and parasitic disease with substantial economic impacts on humans and animals. Many studies have looked at the prevalence of fasciolis worldwide, yet the overall prevalence and risk factors in cattle, ruminants, and humans remains unknown. Methods: We conducted a systematic review and meta-analysis to estimate the global prevalence and risk factors of fascioliasis in humans and domestic ruminants. With this aim, we searched PubMed, ScienceDirect, Web of Science, and Scopus from inception to 8 December 2022 for studies reporting the prevalence of fascioliasis in humans or domestic ruminants post-2000. We then used random effects models to describe the prevalence of fascioliasis; trim-and-fill analysis and Egger's test to assess publication bias; and meta-regression and sensitivity analyses to examine the risk factors for prevalence and heterogeneity. Results: We retrieved 4422 articles, with 371 being included in the analysis, as they concerned fascioliasis in humans and ruminants globally. The pooled prevalence of bovine fasciolosis was 17%, while ovine fasciolosis and human fascioliasis had pooled prevalences of 13% and 5%, respectively. We also conducted subgroup analyses by continents, countries, Fasciola species, sampling years, altitude, rainfall, temperature, humidity, age, sex, feeding mode, and residence. Here, altitude and age emerged as risk factors associated with an increased prevalence of fascioliasis. Both the trim-and-fill analysis and Egger's test confirmed the presence of publication bias, while the sensitivity analysis showed that the omission of any single study did not significantly influence the combined pooled prevalence. Conclusions: Fascioliasis is a widely prevalent zoonosis among humans and livestock worldwide. Strategies targeting risk factors such as altitude and age are urgently needed for prevention and control of this disease, which will consequently reduce Fasciola infection. Additionally, given the inadequacy or absence of data in some countries, greater attention should be paid to Fasciola infection, with further epidemiological studies focussing on improving data quality.
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