Evidence map›Paper›PMID 39297248›Full record

ArticleCPT: pharmacometrics & systems pharmacology2025

Mathematical model of the relationship between pH holding time and erosive esophagitis healing rates.

Colin W Howden, Carmelo Scarpignato, Eckhard Leifke, Darcy J Mulford, Gezim Lahu, Axel Facius, Yuhong Yuan, Richard Hunt

Abstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Beyond PPIs: New Options for Treating GERD.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Colin W HowdenUniversity of Tennessee College of Medicine, Memphis, Tennessee, USA.
Carmelo ScarpignatoDepartment of Health Sciences, United Campus of Malta, Msida, Malta.ORCID 0000-0001-5645-857X
Eckhard LeifkePhathom Pharmaceuticals, Research and Development, Buffalo Grove, Illinois, USA.
Darcy J MulfordPhathom Pharmaceuticals, Research and Development, Buffalo Grove, Illinois, USA.
Gezim LahuthinkQ2 AG, Baar, Switzerland.
Axel FaciusthinkQ2 AG, Baar, Switzerland.ORCID 0000-0003-2624-7098
Yuhong YuanDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Richard HuntDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective suppression of gastric acid secretion promotes healing of erosive esophagitis. Treatment guidelines recommend proton pump inhibitors (PPIs) and histamine H

Indexed as

Histamine H2 AntagonistsProton Pump InhibitorsEsophagitisGastric AcidHumansHydrogen-Ion ConcentrationModels, TheoreticalTime FactorsHistamine H2 AntagonistsProton Pump Inhibitors

Identifiers

PMID39297248
PMCPMC11706433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.