Evidence map›Paper›PMID 39297139›Full record

ArticleJACC. Basic to translational science2024

Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure.

Ying Wang, Meimi Zhao, Xianhui Liu, Bing Xu, Gopireddy R Reddy, Aleksandra Jovanovic, Qingtong Wang, Chaoqun Zhu, Heli Xu, Elizabeth F Bayne and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ying WangDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Meimi ZhaoDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Xianhui LiuDepartment of Entomology and Nematology, University of California-Davis, Davis, California, USA.
Bing XuDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Gopireddy R ReddyDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Aleksandra JovanovicDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Qingtong WangDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Chaoqun ZhuDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Heli XuDepartment of Cardiovascular Sciences, Temple University, Philadelphia, Pennsylvania, USA.
Elizabeth F BayneDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Wenjing XiangDepartment of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Douglas G TilleyDepartment of Cardiovascular Sciences, Temple University, Philadelphia, Pennsylvania, USA.
Ying GeDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Christopher G TateMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Robert FeilInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Joanna C ChiuDepartment of Entomology and Nematology, University of California-Davis, Davis, California, USA.
Donald M BersDepartment of Pharmacology, University of California-Davis, Davis, California, USA.
Yang K XiangDepartment of Pharmacology, University of California-Davis, Davis, California, USA.

Funding

CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Non-transcriptional regulation of circadian physiologyR01DK124068 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2019 to 2026
$3.1M
Non-transcriptional regulation of circadian physiologyR56DK124068 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIU, JOANNA CHUNGYEN · 2023 to 2023
$137k
NHLBI NIH HHS R01 HL142282NIDDK NIH HHS R01 DK124068
6 · The paper itself

Abstract

Phosphorylation of myofilament proteins critically regulates beat-to-beat cardiac contraction and is typically altered in heart failure (HF). β-Adrenergic activation induces phosphorylation in numerous substrates at the myofilament. Nevertheless, how cardiac β-adrenoceptors (βARs) signal to the myofilament in healthy and diseased hearts remains poorly understood. The aim of this study was to uncover the spatiotemporal regulation of local βAR signaling at the myofilament and thus identify a potential therapeutic target for HF. Phosphoproteomic analysis of substrate phosphorylation induced by different βAR ligands in mouse hearts was performed. Genetically encoded biosensors were used to characterize cyclic adenosine and guanosine monophosphate signaling and the impacts on excitation-contraction coupling induced by β

Indexed as

contractilityheart failuremyofilamentmyosin light chainnitric oxide synthetaseprotein kinase Gβ1-adrenoceptor

Identifiers

PMID39297139
PMCPMC11405995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.