Evidence map›Paper›PMID 39296590›Full record

ArticleRespirology case reports2024

Combination effect of Mepolizumab and Endobronchial Watanabe Spigot (EWS) in drug-induced eosinophilic pneumonia complicated by refractory pneumothorax.

Nana Ayame, Yuki Tanabe, Mai Motojima, Ryosuke Tachi, Fumihiko Makino, Shiaki Oh, Shinichi Sasaki, Kazuhisa Takahashi

Abstract readCase Reports
In one paragraph

Article in Respirology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nana AyameDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Yuki TanabeDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID https://orcid.org/0000-0003-1463-2749
Mai MotojimaDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Ryosuke TachiDepartment of General Thoracic Surgery Juntendo University Graduate School of Medicine Tokyo Japan.
Fumihiko MakinoDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Shiaki OhDepartment of General Thoracic Surgery Juntendo University Graduate School of Medicine Tokyo Japan.
Shinichi SasakiDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Kazuhisa TakahashiDepartment of Respiratory Medicine Juntendo University Graduate School of Medicine Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few reports have described the treatment of eosinophilic pneumonia (EP) complicated by refractory pneumothorax. A 62-year-old man with a medical history of ulcerative colitis who was undergoing maintenance treatment presented with fever, cough, and diffuse bilateral consolidation on chest radiography. Laboratory findings showed peripheral eosinophilia, and he was hospitalized with a diagnosis of drug-induced EP and started on corticosteroid therapy. During the course, he developed refractory pneumothorax, and it was difficult to control the air leakage. As it was necessary to control the eosinophilic inflammation and air leakage, mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, and an endobronchial Watanabe spigot (EWS), were introduced. After EWS insertion, the leakage of the refractory pneumothorax disappeared. The patient continued to have no recurrence of EP or pneumothorax after the removal of the EWS. The combination of mepolizumab and an EWS may be effective in cases of EP complicated by refractory pneumothorax.

Indexed as

endobronchial Watanabe spigoteosinophilic pneumoniaEWSmepolizumabrefractory pneumothorax

Identifiers

PMID39296590
PMCPMC11408264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.