Evidence map›Paper›PMID 39296564›Full record

ArticleInternational journal of ophthalmology2024

Etomidate protects retinal ganglion cells from hydrogen peroxide-induced injury

Xuan Zhao, De-Gang Fan, Xin-Chao Zhang, Si-Wei You, Fang Kuang, Ming-Mei Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuan ZhaoDepartment of Histology and Embryology, School of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, Shaanxi Province, China.
De-Gang FanDepartment of Spinal Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China.
Xin-Chao ZhangDepartment of Neurobiology, the Basic Medical Science Academy, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Si-Wei YouDepartment of Neurobiology, the Basic Medical Science Academy, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Fang KuangDepartment of Neurobiology, the Basic Medical Science Academy, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Ming-Mei WuDepartment of Neurobiology, the Basic Medical Science Academy, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine whether etomidate (ET) has a protective effect on retinal ganglion cells (RGCs) injured with hydrogen peroxide (H

methodsCultured RGCs were identified by double immunofluorescent labeling of microtubule-associated protein 2 and Thy1.1. An injury model of H

resultsThe applications of 5 and 10 µmol/L of ET significantly increased the viability of RGCs. Results from qRT-PCR indicated a decrease in the expression of iNOS and an increase in the expressions of Nrf2 and HO-1 in ET-pretreated RGCs at 12, 24 and 48h after H

conclusionET is a neuroprotective agent in primary cultured RGCs injured by H

Indexed as

etomidateheme oxygenase 1hydrogen peroxide-induced injuryneuroprotectionnuclear factor erythroid 2-related factor 2retinal ganglion cell

Identifiers

PMID39296564
PMCPMC11367447

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.