ArticleFrontiers in nutrition2024
Dose-response relationship of dietary Omega-3 fatty acids on slowing phenotypic age acceleration: a cross-sectional study.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Tubular Omega-3 Fatty Acid Receptor FFAR4 Deficiency Aggravated Renal Aging and Chronic Kidney Disease.Aging cell · 2026Article
- Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey.npj aging · 2025Article
- Association of longitudinal body mass index trajectories with phenotypic age acceleration: a cross-sectional study based on growth mixture modeling.GeroScience · 2025Article
- Causal impact of genetically-determined fish and fish oil intake on epigenetic age acceleration and related serum markers.Human genomics · 2025Article
- The state of the art in anti-aging: plant-based phytochemicals for skin care.Immunity & ageing : I & A · 2025Review
- Synergistic Effects of Omega-3 Fatty Acids and Physical Activity on Oxidative Stress Markers and Antioxidant Mechanisms in Aged Rats.Nutrients · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Purpose: This study investigates the association between dietary Omega-3 fatty acid intake and accelerated phenotypic aging, referred to as PhenoAgeAccel. PhenoAgeAccel is defined as the difference between phenotypic biological age, calculated using blood biochemical markers, and chronological age. This study assesses the potential of Omega-3 intake to slow biological aging and its implications for public health. Methods: Utilizing data from the NHANES from 1999 to 2018, this cross-sectional study included 20,337 adult participants. Through a nationally representative sample combined with comprehensive phenotypic age calculation methods, a cross-sectional analysis of Omega-3 fatty acid intake and accelerated phenotypic aging was conducted. Weighted generalized linear regression models and restricted cubic spline analyses were applied to explore the potential non-linear relationships between them. Threshold effects were further clarified through piecewise regression models, and the impact of different demographic and health characteristics was evaluated through interaction effect tests. Results: After adjusting for various potential confounding factors, a significant negative correlation was found between Omega-3 fatty acid intake and PhenoAgeAccel ( Conclusion: This study highlights the potential role of dietary Omega-3 fatty acids in regulating PhenoAgeAccel and supports the strategy of delaying the aging process through dietary interventions to increase Omega-3 intake. The findings of this study contributes to the development of precise nutritional intervention strategies for different populations to optimize healthy longevity.
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