Evidence map›Paper›PMID 39296400›Full record

ArticleBiomedical optics express2024

Unveiling enamel demineralization mechanisms by sensitive dielectric differentiation based on terahertz nanospectroscopy.

Feng Xiao, Xiaoqiuyan Zhang, Xingxing Xu, Tianyu Zhang, Fu Tang, Haowei Yin, Tao Hu, Lei Lei, Li Cheng, Min Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Feng XiaoTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Xiaoqiuyan ZhangTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Xingxing XuTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Tianyu ZhangTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Fu TangTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Haowei YinTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Tao HuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Lei LeiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Li ChengState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Min HuTerahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.ORCID https://orcid.org/0000-0001-6214-4147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early stage of dental caries, i.e. demineralization, has always been a topic of concern to dentists. Understanding the essential mechanism of its occurrence is of great significance for the prevention and treatment of dental caries. However, owing to limitations in resolution and the detection capabilities of diagnostic tools, the study of enamel demineralization has always been a challenge. Terahertz (THz) technology, especially the combination of scanning near-field optical microscopy (s-SNOM) and THz time-domain spectroscopy (TDS), due to its nanoscale resolution, has shown great advantages in the field of biological imaging. Here, a THz s-SNOM system is used to perform near-field imaging of enamel before and after demineralization at the nanoscale. It can be found that near-field signals decrease significantly after demineralization. This is due to the changes of the crystal lattice and the transfer of mineral ions during demineralization, which leads to a decrease in the permittivity of the enamel. The novel approach in this study reveals the essence of demineralization and lays the groundwork for additional research and potential interventions.

Identifiers

PMID39296400
PMCPMC11407262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.