Evidence map›Paper›PMID 39296396›Full record

ArticleBiomedical optics express2024

Longitudinal tracking of perfluorooctanoic acid exposure on mammary epithelial cell spheroids by dynamic optical coherence tomography.

Lin Yang, Pan Ji, Abel A Miranda Buzetta, Haolin Li, Matthew R Lockett, Haibo Zhou, Amy L Oldenburg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin YangDepartment of Physics and Astronomy, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Pan JiDepartment of Physics and Astronomy, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Abel A Miranda BuzettaDepartment of Chemistry, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Haolin LiDepartment of Biostatistics, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Matthew R LockettDepartment of Chemistry, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0003-4851-7757
Haibo ZhouDepartment of Biostatistics, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Amy L OldenburgDepartment of Physics and Astronomy, The University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Developing an in vitro to in vivo pipeline of mammary gland exposure-response relationships to per- and poly-fluoroalkyl substances (PFAS)R01ES032730 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LOCKETT, MATTHEW RYEN, OLDENBURG, AMY L · 2020 to 2024
$2.6M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES032730
6 · The paper itself

Abstract

We investigated the morphology and intracellular motility of mammary epithelial cell (MCF10DCIS.com) spheroids cultured in 3D artificial extracellular matrix under perfluorooctanoic acid (PFOA) exposure. Dynamic optical coherence tomography (OCT) was employed for real-time, non-invasive imaging of these spheroids longitudinally over 12 days under PFOA exposures up to 500 µM. Despite no significant changes in volume or asphericity of spheroids, morphological alterations were observed in OCT images of spheroids at 100 µM on Day 12 and from Day 4 at 500 µM. Intracellular motility was assessed by the inverse-power-law exponent of the speckle fluctuation spectrum (

Identifiers

PMID39296396
PMCPMC11407248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.