Evidence map›Paper›PMID 39296237›Full record

ArticleHeliyon2024

Identification of endoplasmic reticulum stress-associated genes and subtypes for predicting risk signature and depicting immune features in inflammatory bowel disease.

Ziyu Liu, Zahra Zeinalzadeh, Tao Huang, Yingying Han, Lushan Peng, Dan Wang, Zongjiang Zhou, Diabate Ousmane, Junpu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. ER stress genes (Frontiers in immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziyu LiuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Zahra ZeinalzadehDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Tao HuangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Yingying HanDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Lushan PengDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Dan WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Zongjiang ZhouDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Diabate OusmaneDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.
Junpu WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha City, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum stress (ERS) becomes a significant factor in inflammatory bowel disease (IBD), like Crohn's disease (CD) and ulcerative colitis (UC). Our research was aimed at identifying molecular markers to enhance our understanding of ERS and inflammation in IBD, recognizing risk factors and high-risk groups at the molecular level, and developing a predictive model on the grounds of based on ERS-associated genes. This research adopted the least absolute shrinkage and selection operator (LASSO) regression and logistic regression to build a predictive model, and categorized IBD patients into high- and low-risk groups, and then identified four gene clusters. Our key findings included a significant increase in drug target gene expression in high-risk groups, notable discrepancies in immune levels, and functions between high-risk and low-risk groups. Notably, the

Indexed as

Endoplasmic reticulum stressImmune infiltrationInflammatory bowel diseasePersonalized therapyPredictive modelTAP1 gene

Identifiers

PMID39296237
PMCPMC11409092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.