Evidence map›Paper›PMID 39296124›Full record

ArticleHeliyon2024

Unraveling the potential effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on the Protein structure and function of the human

Md Moin Uddin, Md Tanvir Hossain, Md Arju Hossain, Asif Ahsan, Kamrul Hasan Shamim, Md Arif Hossen, Md Shahinur Rahman, Md Habibur Rahman, Kawsar Ahmed, Francis M Bui and 1 more

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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Md Moin UddinDepartment of Biotechnology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Md Tanvir HossainDepartment of Biotechnology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Md Arju HossainDepartment of Microbiology, Primeasia University, Banani, Dhaka 1213, Bangladesh.
Asif AhsanDepartment of Biotechnology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Kamrul Hasan ShamimDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh.
Md Arif HossenDepartment of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh.
Md Shahinur RahmanDepartment of Diabetes and Endocrinology, Pabna Diabetic Association Hospital, Pabna 6600, Bangladesh.
Md Habibur RahmanDepartment of Computer Science and Engineering, Islamic University, Kushtia 7003, Bangladesh.
Kawsar AhmedDepartment of Electrical and Computer Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada.
Francis M BuiDepartment of Electrical and Computer Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada.
Fahad Ahmed Al-ZahraniDepartment of Computer Engineering, Umm Al-Qura University, Mecca 24381, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: The single nucleotide polymorphisms (SNPs) in Materials and methods: Several Results: After data analysis, out of 336 missenses, the eight nsSNPs, namely R138Q, I141N, W136G, I349N, L303R, E140A, W306C, and L308Q, were discovered by ConSurf to be in highly conserved regions, which could affect the stability of their proteins. Project HOPE determines any significant molecular effects on the structure and function of eight mutated proteins and the three-dimensional (3D) structures of these proteins. The two pharmacologically significant compounds, Luzonoid B and Roseoside demonstrate strong binding affinity to the mutant proteins, and they are more efficient in inhibiting them than the typical Conclusion: Finally, the study found eight highly deleterious missense nsSNPs in the

Indexed as

And colorectal cancerMissenseNon-synonymousPolymorphismSLC30A8T2D

Identifiers

PMID39296124
PMCPMC11408818

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.