Evidence map›Paper›PMID 39296104›Full record

ArticleHeliyon2024

Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein expression.

Shuai Ma, Yiqing Hu, Wangguo Xu, Weidong Xiong, Xinyu Xu, Yajie Hou, Ying Wang, Panke Chen, Wenbi Yang, Hao Lu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuai MaDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Yiqing HuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, 200032, Shanghai, China.
Wangguo XuDepartment of Cardiology, Yongchuan Hospital of Chongqing Medical University, 402160, Chongqing, China.
Weidong XiongDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Xinyu XuDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Yajie HouDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Ying WangDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Panke ChenDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Wenbi YangDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.
Hao LuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, 200032, Shanghai, China.
Yongchao ZhaoDepartment of Cardiology, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, Guizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Post-ischemic angiogenesis is crucial for reestablishing blood flow in conditions such as peripheral artery disease (PAD). The role of insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2) in post-transcriptional RNA metabolism and its involvement in post-ischemic angiogenesis remains unclear. Methods: Using a human GEO database and a hind-limb ischemia (HLI) mouse model, the predominant isoform IGF2BP2 in ischemic gastrocnemius tissue was identified. Adeno-associated virus with the Results: HLI reduced IGF2BP2 expression in the gastrocnemius tissue, which gradually increased during blood flow recovery. IGF2BP2 overexpression in HLI mice accelerated blood flow recovery and increased capillary and small artery densities. The overexpression of IGF2BP2 in HUVECs stimulated proliferation, migration, and tube formation by interacting with Conclusions: IGF2BP2 contributes to blood flow restoration post-ischemia

Indexed as

Fibroblast growth factor 2Insulin-like growth factor-2 mRNA-binding protein 2mRNA stabilityPeripheral arterial diseasePost-ischemic angiogenesis

Identifiers

PMID39296104
PMCPMC11409114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.