Evidence map›Paper›PMID 39296024›Full record

ArticleHeliyon2024

Pharmacodynamics of Sishen decoction in relieving rheumatoid arthritis: Chemical composition, regulatory pathway and online prediction simulation.

Mengyao Gao, Jun Liu, Quansheng Li, Yeyu Zhao, Xin Jin, Xinyi Tang, Congxi Li, Mingli Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengyao GaoLiaoning University of Traditional Chinese Medicine, China.
Jun LiuAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Quansheng LiDepartment of Allergy, Shengjing Hospital of China Medical University, Shenyang, China.
Yeyu ZhaoLiaoning University of Traditional Chinese Medicine, China.
Xin JinAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Xinyi TangLiaoning University of Traditional Chinese Medicine, China.
Congxi LiLiaoning University of Traditional Chinese Medicine, China.
Mingli GaoLiaoning University of Traditional Chinese Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a commonly used traditional Chinese medicine formula for treating rheumatoid arthritis (RA), Sishen Decoction (SSD) has anti-inflammatory, analgesic and swelling relief effects. However, at present, the pharmacodynamic basis of SSD and its mechanism of treating RA have not been clarified, and further research is needed. Analyzing the pharmacological basis of SSD was the aim of our study and further elucidate its therapeutic mechanism and potential targets for treating RA. LC‒MS was used to identify the high content and characteristic chemical components of SSD. On this basis, a network of pharmacological analysis was established between the chemical structure and RA. According to the predicted possible pathways and targets,

Indexed as

Chemical compositionComputational simulationPI3K/AKT pathwayRheumatoid arthritisSishen decoction

Identifiers

PMID39296024
PMCPMC11409070

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.