Evidence map›Paper›PMID 39295863›Full record

ArticleFrontiers in immunology2024

Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant

Christine C A van Linge, Robert F J Kullberg, Osoul Chouchane, Joris J T H Roelofs, Wil H F Goessens, Cornelis van 't Veer, Jean-Claude Sirard, Alex F de Vos, Tom van der Poll

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Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Butyrate-producing gut bacteriumThe European respiratory journal · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christine C A van LingeCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Robert F J KullbergCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Osoul ChouchaneCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Joris J T H RoelofsAmsterdam Infection & Immunity Institute, Amsterdam, Netherlands.
Wil H F GoessensDepartment of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
Cornelis van 't VeerCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Jean-Claude SirardCenter for Infection and Immunity of Lille, Institut Pasteur de Lille, U1019 - UMR9017, centre hospitalier universitaire (CHU) Lille, Centre national de la recherche scientifique (CNRS), L'institut national de la santé et de la recherche médicale (INSERM), University of Lille, Lille, France.
Alex F de VosCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Tom van der PollCenter for Experimental and Molecular Medicine, Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Antimicrobial resistance is an emerging problem and multi-drug resistant (MDR) Methods: C57BL6 mice were inoculated intranasally with hypervirulent Results: Flagellin therapy induced neutrophil influx in the lung during antibiotic-treated pneumonia evoked by either antibiotic-susceptible or -resistant Conclusion: Topical flagellin administration as an adjunctive to antibiotic treatment augments neutrophil responses during pneumonia evoked by MDR-

Indexed as

Drug Resistance, Multiple, BacterialFlagellinKlebsiella InfectionsKlebsiella pneumoniaeMice, Inbred C57BLNeutrophilsAdministration, TopicalAnimalsAnti-Bacterial AgentsBacterial LoadDisease Models, AnimalLungMiceNeutrophil InfiltrationAnti-Bacterial AgentsFlagellinantimicrobial resistanceflagellinKlebsiella pneumoniaepneumoniarespiratory infection

Identifiers

PMID39295863
PMCPMC11408203

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.