Evidence map›Paper›PMID 39295784›Full record

ReviewFrontiers in bioinformatics2024

PhIP-Seq: methods, applications and challenges.

Ziru Huang, Samarappuli Mudiyanselage Savini Gunarathne, Wenwen Liu, Yuwei Zhou, Yuqing Jiang, Shiqi Li, Jian Huang

Abstract readReview
In one paragraph

Review in Frontiers in bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. B-EPIC: A Transformer-Based Language Model for Decoding B Cell Immunodominance Patterns.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ziru HuangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Samarappuli Mudiyanselage Savini GunarathneSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Wenwen LiuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Yuwei ZhouSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Yuqing JiangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Shiqi LiSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Jian HuangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage-immunoprecipitation sequencing (PhIP-Seq) technology is an innovative, high-throughput antibody detection method. It enables comprehensive analysis of individual antibody profiles. This technology shows great potential, particularly in exploring disease mechanisms and immune responses. Currently, PhIP-Seq has been successfully applied in various fields, such as the exploration of biomarkers for autoimmune diseases, vaccine development, and allergen detection. A variety of bioinformatics tools have facilitated the development of this process. However, PhIP-Seq technology still faces many challenges and has room for improvement. Here, we review the methods, applications, and challenges of PhIP-Seq and discuss its future directions in immunological research and clinical applications. With continuous progress and optimization, PhIP-Seq is expected to play an even more important role in future biomedical research, providing new ideas and methods for disease prevention, diagnosis, and treatment.

Indexed as

antibodybiotechnological applicationsimmunityphagePhIP-Seq

Identifiers

PMID39295784
PMCPMC11408297

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.