Evidence map›Paper›PMID 39295242›Full record

ArticleJournal of biomedical materials research. Part A2025

Differential effects of macrophage subtype-specific cytokines on fibroblast proliferation and endothelial cell function in co-culture system.

Ilaha Isali, Phillip McClellan, Thomas R Wong, Sara Hijaz, David R Fletcher, Guiming Liu, Tracey L Bonfield, James M Anderson, Adonis Hijaz, Ozan Akkus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Progress in immunoregulatory mechanisms during distraction osteogenesis.Frontiers in bioengineering and biotechnology · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilaha IsaliDepartment of Urology, Weill Cornell Medicine, New York, New York, USA.
Phillip McClellanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-6151-5070
Thomas R WongDepartment of Urology, Case Western Reserve University, Cleveland, Ohio, USA.
Sara HijazDepartment of Urology, Case Western Reserve University, Cleveland, Ohio, USA.
David R FletcherCase Western Reserve University, Department of Genetics and Genome Sciences, Cleveland, Ohio, USA.
Guiming LiuDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio, USA.
Tracey L BonfieldCase Western Reserve University, Department of Genetics and Genome Sciences, Cleveland, Ohio, USA.
James M AndersonDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Adonis HijazDepartment of Urology, Case Western Reserve University, Cleveland, Ohio, USA.
Ozan AkkusDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

TRAINING PROGRAM IN MUSCULOSKELETAL RESEARCHT32AR007505 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI TRIOLO, RONALD J · 1986 to 2023
$6.3M
KUH-TN Training CoreTL1DK132770 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Evi X. Stavrou · 2021 to 2026
$2.5M
Immunoregenerative treatment of Stress Urinary Incontinence by Autologous Macrophage TherapyR21HD095439 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI AKKUS, OZAN, HIJAZ, ADONIS K · 2018 to 2019
$440k
Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve UniversityNIAMS NIH HHS T32 AR007505NICHD NIH HHS R21 HD095439NIDDK NIH HHS TL1 DK132770NIH HHS R21HD095439NIH HHS T32AR007505NIH HHS TL1DK132770
6 · The paper itself

Abstract

Macrophages are involved in several critical activities associated with tissue repair and regeneration. Current approaches in regenerative medicine are focusing on leveraging the innate immune response to accelerate tissue regeneration and improve long-term healing outcomes. Of particular interest in this regard are the currently known, four main M2 macrophage subtypes: M2

Indexed as

Cell ProliferationCoculture TechniquesCytokinesFibroblastsMacrophagesAnimalsEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsMaleRatsCytokinesM2 macrophagesmacrophagestissue repair

Identifiers

PMID39295242
PMCPMC11669535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.