Evidence map›Paper›PMID 39295085›Full record

ArticleBrain and behavior2024

Dose-dependent cranial irradiation associations with brain structures and neuropsychological outcomes in children with posterior fossa brain tumors.

Mary Baron Nelson, Sharon H O'Neil, Scarlet J Cho, Sofia Dhanani, Jeffrey Tanedo, Brandon J Shin, Jack Rodman, Arthur Olch, Kenneth Wong, Marvin D Nelson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mary Baron NelsonDepartment of Radiology, Keck School of Medicine of USC, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-4101-4877
Sharon H O'NeilCIBORG Laboratory, Children's Hospital Los Angeles, Los Angeles, California, USA.
Scarlet J ChoCIBORG Laboratory, Children's Hospital Los Angeles, Los Angeles, California, USA.
Sofia DhananiCIBORG Laboratory, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8337-8409
Jeffrey TanedoCIBORG Laboratory, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-7421-4066
Brandon J ShinCIBORG Laboratory, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0009-0009-1870-6136
Jack RodmanBiostatistics, Epidemiology, and Research Design (BERD), Southern California Translational Science Institute, Los Angeles, California, USA.
Arthur OlchDepartment of Radiation Oncology, Keck School of Medicine of USC and Radiation Oncology Program, Children's Hospital Los Angeles, Los Angeles, California, USA.
Kenneth WongDepartment of Radiation Oncology, Keck School of Medicine of USC and Radiation Oncology Program, Children's Hospital Los Angeles, Los Angeles, California, USA.
Marvin D NelsonDepartment of Radiology, Keck School of Medicine of USC, Los Angeles, California, USA.
Jonathan FinlayNationwide Children's Hospital, Columbus, Ohio, USA.
Natasha LeporeDepartment of Radiology, Keck School of Medicine of USC, Los Angeles, California, USA.

Funding

Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Treatment-related CNS Injury in Children with Brain TumorsK23NR014902 · NINR · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BARON NELSON, MARY · 2014 to 2016
$396k
Children's Hospital Los Angeles Hemonc/BMT Division Research Funds; The Saban Research Institute (TSRI) of Children's Hospital Los Angeles; USC CTSI REDCap UL1TR001855National Center for Advancing Translational Sciences (NCATS) at the NIH UL1TR000130NINR NIH HHS K23NR014902
6 · The paper itself

Abstract

backgroundPosterior fossa irradiation with or without whole brain irradiation results in high doses of radiation to the thalamus, hippocampus, and putamen, structures critical to cognitive functioning. As a result, children with brain tumors treated with cranial irradiation (CRT) may experience significant cognitive late effects. We sought to determine the effect of radiation to those structures on neuropsychological outcome.

methodsForty-seven children with a history of posterior fossa tumor (17 treated with surgery; 11 with surgery and chemotherapy; and 19 with surgery, chemotherapy, and CRT) underwent neuroimaging and neuropsychological assessment at a mean of 4.8 years after treatment, along with 17 healthy sibling controls. The putamen, thalamus, and hippocampus were segmented on each participant's magnetic resonance imaging for diffusion indices and volumes, and in the radiation treatment group, radiation dose to each structure was calculated.

resultsPerformance on visuoconstruction and spatial learning and memory was lower in patient groups than controls. Volume of the thalamus, when controlling for age, was smaller in the patient group treated with CRT than other groups. Higher radiation doses to the putamen correlated with higher fractional anisotropy in that structure. Higher radiation dose to the hippocampus correlated with lower spatial learning, and higher dose to thalami and putamina to lower verbal and nonverbal reasoning.

conclusionsAll children with posterior fossa tumors, regardless of treatment modality, had cognitive deficits compared to their sibling controls. Posterior fossa irradiation may affect thalamic volume and aspects of verbal and nonverbal cognitive functioning.

Indexed as

Cranial IrradiationInfratentorial NeoplasmsAdolescentBrainChildDose-Response Relationship, RadiationFemaleHippocampusHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPutamenThalamuscognitive functioningcranial irradiationmagnetic resonance imagingposterior fossa tumor

Identifiers

PMID39295085
PMCPMC11410875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.