ArticleBMC ophthalmology2024
Retinal nerve fiber layer thickness and radial peripapillary capillaries density in myopic adults with optical coherence tomography angiography.
Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Quadrant-specific anatomical architecture of the peripapillary retinal nerve fiber layer: a spectral-domain optical coherence tomography study.Surgical and radiologic anatomy : SRA · 2026Article
- Retinal and Choroidal Microvasculature at Different Myopia Severities: A Systematic Review and Meta-Analysis.Ophthalmology science · 2026Review
- Short-Term Changes in Peripapillary RNFL and Disc-Fovea Angle After Horizontal Rectus Muscle Surgery in Comitant Strabismus.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Swept-Source OCT Angiography-Derived Regional Normative Data of Peripapillary Vessel Density in Healthy Populations.Translational vision science & technology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate retinal nerve fiber layer thickness (RNFLT) and radial peripapillary capillaries (RPC) density in adults with different degrees of myopia using optical coherence tomography angiography (OCTA) and explore their relationship with ocular factors, such as axial length (AL) and disc area.
methodsA total of 188 subjects were included in this cross-sectional study. The eyes were divided into four groups according to AL. OCTA was used for the assessment of RNFLT, RPC density, and other optic disc measurements, such as disc area. One-way analysis of variance was performed to compare differences between four groups, and P value < 0.01 was considered significant.
resultsThe RNFLT was significantly thinner in high myopia (HM) group at inferior nasal (IN) quadrant (P = 0.004) than low myopia (LM) group, but thicker at temporal inferior (TI) quadrant (P = 0.006). The RPC density of nasal superior (NS) quadrant, nasal inferior (NI) quadrant, and inferior nasal (IN) quadrant significantly decreased as AL increasing. By simple linear regression analysis, the inside disc RPC (iRPC) density tended to be correlated significantly with AL (0.3997%/mm, P < 0.0001). Peripapillary RPC (pRPC) density was in significant correlation with AL (-0.2791%/mm, P = 0.0045), and peripapillary RNFLT (pRNFLT) was in significant correlation with disc area (0.2774%/mm
conclusionRNFLT and RPC density were closely associated with AL and disc area. They might be new indexes in assessing and detecting myopia development via OCTA.
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