ArticleEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity2024
Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.
Article in European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Vitamin D Deficiency in Institutionalized Older Adults: Associations with Supplementation Practices but Not with Cognitive Decline or Dementia.Nutrients · 2026Article
- Changes in physical activity across retirement: a compositional data analysis approach in a Swedish cohort study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Determinants of physical activity levels and quality of life among older adults in Ghana: insights from cardiometabolic risk (CarMeR) study.Archives of public health = Archives belges de sante publique · 2025Article
- Physical Inactivity and Cardiovascular Health in Aging Populations: Epidemiological Evidence and Policy Implications from Riyadh, Saudi Arabia.Life (Basel, Switzerland) · 2025Article
- Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice.Frontiers in molecular neuroscience · 2025Article
- Healthy community-living older adults' experiences with using a specially adapted virtual reality exercise game to promote physical activity-a pilot study.Frontiers in sports and active living · 2025Article
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Authors and funding
10 authors.
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Abstract
backgroundWe aimed to characterize the associations between physical activity levels and the risk of developing age-related diseases in the Coronary Artery Risk Development in Young Adults (CARDIA) study and used Mendelian randomization (MR) to assess whether there are causal relationships between physical activity levels and the risk of developing 8 age-related diseases (coronary atherosclerosis, ischemic heart disease, angina, Alzheimer's disease, hypertension, type 2 diabetes, hyperlipidemia, and venous thromboembolism).
methodsBased on the data available in the CARDIA, we obtained data related to five disease states: coronary heart disease, hypertension, diabetes, hyperlipidemia, and venous thromboembolism. Binary logistic regression analysis estimated the multivariable-adjusted associations between different physical activity statuses and diseases. For the MR study, we used summary-level data from a recently published genome-wide association study on physical activity (including vigorous physical activity and accelerometer-based physical activity) conducted with participants from the UK Biobank study. We selected the above 8 age-related diseases as our outcomes.
resultsIn the CARDIA-based analysis, the risk of developing coronary heart disease [OR (95% CI): 0.562 (0.397-0.795)], hypertension [OR (95% CI): 0.703 (0.601-0.821)], diabetes [OR (95% CI): 0.783 (0.620-0.988)], and hyperlipidemia [OR (95% CI): 0.792 (0.662-0.949)] was negatively related to physical activity status when participants achieved the physical activity target. Our MR results support a negative causal association between genetically determined vigorous physical activity levels and the risk of developing 3 age-related diseases, namely, angina, hypertension and type 2 diabetes. Moreover, our results also support a negative causal association between genetically determined accelerometer-based physical activity levels and the risk of developing angina.
conclusionsPromotion of physical activity is likely to prevent specific age-related diseases.
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