Evidence map›Paper›PMID 39294526›Full record

ArticleEuropean journal of epidemiology2024

Danish population based study of familial epilepsy and childhood cancer.

Corbin C Platamone, Chuanjie Deng, Rajarshi Mazumder, Beate Ritz, Jorn Olsen, Johnni Hansen, Chai Saechao, Julia E Heck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Corbin C PlatamoneDepartment of Epidemiology, Fielding School of Public Health, University of California (UCLA), Box 951772, Los Angeles, CA, 90095-1772, USA.
Chuanjie DengDepartment of Epidemiology, Fielding School of Public Health, University of California (UCLA), Box 951772, Los Angeles, CA, 90095-1772, USA.
Rajarshi MazumderDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California (UCLA), Box 951772, Los Angeles, CA, 90095-1772, USA.
Jorn OlsenDepartment of Clinical Epidemiology, Aarhus University, Olof Palmes Allé 43-45, Aarhus N, 8200, Denmark.
Johnni HansenDanish Cancer Institute, Strandboulevarden 49, Copenhagen, DK-2100, Denmark.
Chai SaechaoUCLA Health, University of California (UCLA), 757 Westwood Plaza, Los Angeles, CA, 90095, USA.
Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California (UCLA), Box 951772, Los Angeles, CA, 90095-1772, USA. julia.heck@unt.edu.

Funding

Etiological Role of Parasitic Exposure and Familial Susceptibility in Nodding Syndrome-Related EpilepsiesK01TW012178 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rajarshi Mazumder · 2022 to 2026
$957k
Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
Alex's Lemonade Stand Foundation for Childhood Cancer 17-01882FIC NIH HHS K01 TW012178FIC NIH HHS K01TW012178Foundation for the National Institutes of Health R21CA175959, R03ES021643NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643
6 · The paper itself

Abstract

Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95% CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.14, 95% CI = 1.00, 1.30), and central nervous system tumors (CNS) (OR = 1.36, 95% CI = 1.04, 1.76) as well as neuroblastoma (OR = 1.76, 95% CI = 1.06, 2.90) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.99, 95% CI = 0.99, 4.00).

Indexed as

AnticonvulsantsEpilepsyNeoplasmsAdolescentAdultChildChild, PreschoolDenmarkFemaleHumansInfantInfant, NewbornLogistic ModelsMaleOdds RatioPregnancyAnticonvulsantsAntiepileptic medicationsChildhood cancerDanish population based studyIn-utero exposureMaternal epilepsy

Identifiers

PMID39294526
PMCPMC11520250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.