Evidence map›Paper›PMID 39294491›Full record

ArticleNature neuroscience2024

Inhibiting Ca

Nils Korte, Anna Barkaway, Jack Wells, Felipe Freitas, Huma Sethi, Stephen P Andrews, John Skidmore, Beth Stevens, David Attwell

Abstract read
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
  2. Review
  3. Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Rediscovery of pericytes within the neurovascular unit for cerebral ischemia/reperfusion injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  10. Chemogenetic modulation of CNS pericytes: Impact on pericyte CaMolecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nils KorteDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK. nils.korte@childrens.harvard.edu.
Anna BarkawayDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Jack WellsUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-4171-3539
Felipe FreitasDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Huma SethiDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Stephen P AndrewsALBORADA Drug Discovery Institute, University of Cambridge, Cambridge, UK.
John SkidmoreALBORADA Drug Discovery Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9108-7858
Beth StevensDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4226-1201
David AttwellDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, UK. d.attwell@ucl.ac.uk.ORCID http://orcid.org/0000-0003-3618-0843

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) 740427NICHD NIH HHS P50 HD105351RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) LiDO PhD studentshipRCUK | Medical Research Council (MRC) MR/X010511/1U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) NIH P50 HD105351Wellcome TrustWellcome Trust 219366
6 · The paper itself

Abstract

Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and, thus, decreasing cerebral blood flow (CBF). Therapeutic approaches to attenuate pericyte-mediated constriction in AD are lacking. Here, using in vivo two-photon imaging with laser Doppler and speckle flowmetry and magnetic resonance imaging, we show that Ca

Indexed as

Alzheimer DiseaseCalcium Channel BlockersCerebrovascular CirculationDisease Models, AnimalPericytesAmyloid beta-PeptidesAnimalsCalciumCalcium Channels, L-TypeHumansMaleMiceMice, Inbred C57BLMice, TransgenicNimodipineAmyloid beta-PeptidesCalciumCalcium Channel BlockersCalcium Channels, L-TypeNimodipine

Identifiers

PMID39294491
PMCPMC11537984

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.