ArticleNature2024
Two-factor authentication underpins the precision of the piRNA pathway.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs.Molecular cell · 2026Article
- Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis.bioRxiv : the preprint server for biology · 2026Article
- MORC1 coordinates TRIM28 interaction and nuclear condensate formation for transposon silencing.iScience · 2026Article
- Beyond Junk DNA: Emerging Roles of Non-Coding RNAs in Cancer and Therapeutic Innovation.Biomolecules · 2026Review
- Transposable element regulation in mammalian germ cells and other contexts: multilayered repression, fertility, and regulated activation.Epigenomics · 2026Review
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- Review
- The crosstalk network of non-coding RNAs: Emerging opportunities for the clinical application of osteoporosis.Non-coding RNA research · 2026Review
- A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.The EMBO journal · 2026Article
- Article
- Spermatogenesis Beyond DNA: Integrated RNA Control of the Epitranscriptome and Three-Dimensional Genome Architecture.Current issues in molecular biology · 2026Review
- Gonocytes in Transition: Establishing the Male Germline Identity.Advances in experimental medicine and biology · 2026Review
- Article
- DNA methylation dictates histone modifications in developing male germ cells in the mouse.Nucleic acids research · 2025Article
- Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease.Nature reviews. Molecular cell biology · 2025Review
- The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3' UTRs.bioRxiv : the preprint server for biology · 2025Article
- Transposable elements in health and disease: Molecular basis and clinical implications.Chinese medical journal · 2025Review
- Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials.Pharmaceutics · 2025Review
- Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis.Biomolecules · 2025Article
- Hsa_piR_016975 Is a Novel Target of Nanotherapy that Boosts Hepatoma Progression and Sorafenib Resistance by Abating Maspin/GPX4-Mediated Ferroptosis.Biomaterials research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Madeleine Dias MirandelaCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1253-9877
Ansgar Zoch *Centre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2071-1590
Jessica Leismann *Institute of Molecular Biology, Mainz, Germany.
Shaun Webb *Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4956-3766
Rebecca V BerrensIDRM, Department of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0003-1224-8030
Devisree ValsakumarWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8279-6369
Yuka KabayamaCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8340-7196
Tania AuchynnikavaWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Martina SchitoCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.
Tamoghna ChowdhuryCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.ORCID 0009-0004-6287-7227
David MacLeodCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.
Xinyu XiangCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK.
Juan ZouWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2594-6217
Juri RappsilberWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5999-1310
Robin C AllshireWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8005-3625
Philipp VoigtEpigenetics Programme, Babraham Institute, Cambridge, UK.ORCID 0000-0003-4366-0490
Atlanta G CookWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2087-9772
Joan BarauInstitute of Molecular Biology, Mainz, Germany.
Dónal O'CarrollCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.ORCID 0000-0002-8626-2217
Funding
Wellcome Trust
Abstract
The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice
Indexed as
Adaptor Proteins, Signal TransducingArgonaute ProteinsCell Cycle ProteinsDNA MethylationDNA Transposable ElementsLong Interspersed Nucleotide ElementsMicrotubule-Associated ProteinsNuclear ProteinsPhosphoproteinsPiwi-Interacting RNAAllelesAnimalsFemaleHistonesMaleMiceAdaptor Proteins, Signal TransducingArgonaute ProteinsCell Cycle ProteinsDNA Transposable Elementshistone H3 trimethyl Lys4HistonesMicrotubule-Associated ProteinsNuclear ProteinsPhosphoproteinsPiwi-Interacting RNAPIWIL4 protein, mouseRNA PrecursorsspindlinSpocd1 protein, mouse
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.