Evidence map›Paper›PMID 39294372›Full record

ArticleNature2024

Endogenous opioid signalling regulates spinal ependymal cell proliferation.

Wendy W S Yue, Kouki K Touhara, Kenichi Toma, Xin Duan, David Julius

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Spinal cord morphology and PKD2L1Frontiers in neuroanatomy · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wendy W S YueDepartment of Physiology, University of California, San Francisco, CA, USA. wingszewendy.yue@ucsf.edu.ORCID 0000-0002-7736-4262
Kouki K TouharaDepartment of Physiology, University of California, San Francisco, CA, USA.
Kenichi TomaDepartment of Ophthalmology, University of California, San Francisco, CA, USA.
Xin DuanDepartment of Ophthalmology, University of California, San Francisco, CA, USA.ORCID 0000-0001-5260-8972
David JuliusDepartment of Physiology, University of California, San Francisco, CA, USA. david.julius@ucsf.edu.ORCID 0000-0002-6365-4867

Funding

Natural products as probes of the pain pathwayR35NS105038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2018 to 2025
$9.0M
BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell TypesU01NS136405 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan, Evan Harriman Feinberg · 2024 to 2026
$5.9M
Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal CircuitsR01EY030138 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan · 2020 to 2026
$3.2M
NEI NIH HHS R01 EY030138NINDS NIH HHS R35 NS105038NINDS NIH HHS U01 NS136405
6 · The paper itself

Abstract

After injury, mammalian spinal cords develop scars to confine the lesion and prevent further damage. However, excessive scarring can hinder neural regeneration and functional recovery

Indexed as

Cell ProliferationCicatrixEpendymaOpioid PeptidesSignal TransductionSpinal CordSpinal Cord InjuriesAnimalsCerebrospinal FluidEnkephalinsFemaleMaleMiceMice, Inbred C57BLMotor SkillsNeuronsEnkephalinsOpioid PeptidespreproenkephalinProtein PrecursorsReceptors, Opioid, kappa

Identifiers

PMID39294372
PMCPMC12935313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.