ArticleNature2024
Pathogenic hypothalamic extracellular matrix promotes metabolic disease.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- The insulin resistance mosaic: defect, defence or both? A perspective on what insulin resistance means and whether it should be treated.Diabetologia · 2026Article
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Article
- Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.Molecular neurodegeneration · 2026Article
- Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.Nature communications · 2026Article
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease.Reviews in endocrine & metabolic disorders · 2026Review
- A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Extracellular matrix remodelling in neurological diseases.Nature reviews. Neurology · 2026Review
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.NPJ Parkinson's disease · 2026Article
- Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026Review
- THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons.bioRxiv : the preprint server for biology · 2026Article
- Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations.Molecular metabolism · 2026Article
- A modern reinterpretation of the "kidney governs bone" theory: systemic regulation of the neuro-endocrine-immune network via the brain-bone axis and traditional chinese medicine intervention strategies.Frontiers in pharmacology · 2026Review
- Dietary and metabolic reprogramming alleviates neurodegeneration: a review of mechanisms and clinical implications.Frontiers in nutrition · 2026Review
- Central neural circuits and their associated mechanisms of inter-organ crosstalk.Frontiers in cell and developmental biology · 2026Review
- Hypoglycemia induces brain metabolic reprogramming and neurodegeneration via serum response factor and myocardin-related transcription factor-A.Signal transduction and targeted therapy · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
Corrections and comments
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Authors and funding
19 authors.
Cait A BeddowsDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0009-0007-8560-0329
Feiyue ShiDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0009-0007-8785-3813
Anna L HortonDepartment of Biochemistry and Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-0140-0757
Sagar DalalARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0003-2838-1901
Ping ZhangDepartment of Chemistry, University of Calgary, Calgary, Alberta, Canada.
Chang-Chun LingDepartment of Chemistry, University of Calgary, Calgary, Alberta, Canada.
V Wee YongDepartment of Clinical Neurosciences and the Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-2600-3563
Kim LohSt Vincent's Institute of Medical Research, Melbourne, Victoria, Australia.
Ellie ChoBiological Optical Microscopy Platform, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-2932-1890
Chris KaragiannisCentre for Muscle Research, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0009-0007-7063-0162
Adam J RoseDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-9132-8244
Magdalene K MontgomeryDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.
Paul GregorevicCentre for Muscle Research, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-7418-8945
Matthew J WattDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-4064-4188
Nicolle H PackerARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0002-7532-4021
Benjamin L ParkerDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-1818-2183
Robyn M BrownDepartment of Biochemistry and Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia.
Edward S X MohARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0003-4289-0147
Garron T DoddDepartment of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia. garron.dodd@unimelb.edu.au.ORCID 0000-0002-7554-4876
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance
Indexed as
Arcuate Nucleus of HypothalamusChondroitin Sulfate ProteoglycansExtracellular MatrixInsulin ResistanceMetabolic DiseasesAnimalsInsulinMaleMiceMice, Inbred C57BLMice, ObeseNeuronsObesityRatsRats, Sprague-DawleyChondroitin Sulfate ProteoglycansInsulin
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.