ArticleCommunications biology2024
Fingerprints of brain disease: connectome identifiability in Alzheimer's disease.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- Developmental Brain Network Trajectories Differentiate Resilience and Vulnerability to Psychosis in 22q11.2 Deletion Syndrome.Biological psychiatry global open science · 2026Article
- Neural manifold connectomics reveals multiregime functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- Brain connectivity fingerprinting as a predictive biomarker of art therapy outcomes in Parkinson's disease.Research square · 2026Article
- Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.IEEE open journal of engineering in medicine and biology · 2026Article
- Patient-specific functional networks track early cognitive alterations and minor hallucinations in Parkinson's disease.Nature. Mental health · 2026Article
- Dynamic functional connectivity and transcriptomic signatures reveal stage-dependent brain network dysfunction in Alzheimer's disease spectrum.Alzheimer's research & therapy · 2025Article
- Silent Witnesses: Exploring the Impact of Cone Beam Computed Tomography on Forensic Investigations.Cureus · 2025Review
- Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
- Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?Brain communications · 2025Review
- Spine-prints: Transposing brain fingerprints to the spinal cord.Imaging neuroscience (Cambridge, Mass.)Article
- Neurophysiological screening of individual variability for robust decoding in c-VEP-based BCI.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Functional connectivity patterns in the human brain, like the friction ridges of a fingerprint, can uniquely identify individuals. Does this "brain fingerprint" remain distinct even during Alzheimer's disease (AD)? Using fMRI data from healthy and pathologically ageing subjects, we find that individual functional connectivity profiles remain unique and highly heterogeneous during mild cognitive impairment and AD. However, the patterns that make individuals identifiable change with disease progression, revealing a reconfiguration of the brain fingerprint. Notably, connectivity shifts towards functional system connections in AD and lower-order cognitive functions in early disease stages. These findings emphasize the importance of focusing on individual variability rather than group differences in AD studies. Individual functional connectomes could be instrumental in creating personalized models of AD progression, predicting disease course, and optimizing treatments, paving the way for personalized medicine in AD management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.