Evidence map›Paper›PMID 39294204›Full record

ArticleScientific reports2024

Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis.

Daniel N A Tagoe, Adeline Ribeiro E Silva, Allison A Drozda, Isabelle Coppens, Bradley I Coleman, Marc-Jan Gubbels

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. HarnessingAnnals of medicine · 2026
    Review
  2. Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Elucidating the Role ofBiomolecules · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Ferlins and TgDOC2 inLife (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel N A Tagoe *Department of Biology, Boston College, Chestnut Hill, MA, 02467, USA.
Adeline Ribeiro E Silva *Department of Biology, Boston College, Chestnut Hill, MA, 02467, USA.
Allison A DrozdaDepartment of Biology, Boston College, Chestnut Hill, MA, 02467, USA.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Bradley I ColemanDepartment of Biology, Boston College, Chestnut Hill, MA, 02467, USA.
Marc-Jan GubbelsDepartment of Biology, Boston College, Chestnut Hill, MA, 02467, USA. gubbelsj@bc.edu.

Funding

Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
Proteomic mapping of differential secretion in Toxoplasma gondiiR03AI122042 · NIAID · BOSTON COLLEGE · PI GUBBELS, MARC-JAN, WEERAPANA, ERANTHIE · 2016 to 2017
$157k
Molecular Discovery and Characterization within Toxoplasma Egress PathwaysF32AI108251 · NIAID · BOSTON COLLEGE · PI COLEMAN, BRADLEY IAN · 2014 to 2014
$55k
American Cancer Society RSG-12-175-01-MPCHSRD VA RRP 12-175National Science Foundation 1626072NIAID NIH HHS R03 AI122042NIH HHS AI060767NIH HHS AI108251NIH HHS AI122042
6 · The paper itself

Abstract

Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations differentiated by dependence on Rab5A/C in their biogenesis. Calcium-dependent exocytosis of micronemes occurs at the very apical tip and is critical for parasite egress from its host cell, adhesion and invasion of the next cell. Ferlins represent a protein family with roles in exocytosis containing multiple Ca

Indexed as

ExocytosisProtein TransportProtozoan ProteinsToxoplasmaCell MembraneHumansOrganellesProtozoan ProteinsExocytosisFerlinMicronemeToxoplasmaTrafficking

Identifiers

PMID39294204
PMCPMC11410953

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.