Trial reportNature communications2024
BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections.
Erratum issuedAbstract readRandomized Controlled TrialClinical Trial, Phase I
In one paragraph
Trial report in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug-resistantClinical microbiology reviews · 2025Pooled it
- Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old War.Journal of molecular biology · 2026Review
- Antibiotic development and a path to access in India.Nature communications · 2026Article
- Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.Chemical Society reviews · 2026Review
- Membrane-Focused Strategies AgainstAntibiotics (Basel, Switzerland) · 2026Review
- Precision antimicrobials: the next paradigm shift after broad-spectrum therapy.Frontiers in microbiology · 2026Article
- Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity.Communications biology · 2025Article
- Effects of Lactic Acid Bacteria Inoculants on Fermentation Quality, Bacteria Communities and Antibiotic Resistance Genes in Whole-Crop Corn Silage.Microorganisms · 2025Article
- Antibiotics re-booted-time to kick back against drug resistance.npj antimicrobials and resistance · 2025Review
- Structural and Mechanistic Insights into Atypical Bacterial Topoisomerase Inhibitors.ACS medicinal chemistry letters · 2025Article
- Anti-Mycobacterial Activity of Bacterial Topoisomerase Inhibitors with Dioxygenated Linkers.ACS infectious diseases · 2025Article
- Computational-aided drug design strategies for drug discovery and development against oral diseases.Frontiers in pharmacology · 2025Review
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
49 authors.
Shahul Hameed PBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Harish KotakondaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Sreevalli SharmaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.ORCID 0000-0001-6055-7853
Radha NandishaiahBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Nainesh KatagihallimathBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Ranga RaoBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Claire SadlerApconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK.
Ian SlaterApconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK.
Michael MortonApconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK.
Abhijeeth ChandrasekaranRxMD, 320/1, Lloyds Road, Royapettah, Chennai, 600 014, India.ORCID 0000-0001-8673-2410
Ed GriffenMedchemica Ltd., No. 8162245, Ebenezer House, Newcastle-under-Lyme, Staffordshire, ST5 2BE, England.ORCID 0000-0003-0859-554X
Dhanashree PillaiBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Sambasiva ReddyBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Nagakumar BharathamBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Suryanarayanan VenkatesanBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Venugopal JonnalagaddaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.ORCID 0000-0001-6684-7739
Ramesh JayaramanTheraIndx Lifesciences Pvt. Ltd., Sy No. 27, Deganahalli, Bangalore, 562123, India.
Mahesh NanjundappaTheraIndx Lifesciences Pvt. Ltd., Sy No. 27, Deganahalli, Bangalore, 562123, India.
Maitrayee SharmaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Savitha RaveendranBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Sreenath RajagopalBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.ORCID 0000-0002-5041-8814
Harikrishna TummaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Amy WattersJMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA.
Holly BeckerJMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA.
Jill LindleyJMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA.
Robert FlammJMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA.
Michael HubandJMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA.
Dan SahmIHMA USA, 2122 Palmer Drive, Schaumburg, IL, 60173-3817, USA.
Meredith HackelIHMA USA, 2122 Palmer Drive, Schaumburg, IL, 60173-3817, USA.
Tarun MathurIHMA India, Gurugram, Haryana, 122018, India.
Ruwanthi Kolamunnage-DonaInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK.
Jennifer UnsworthInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK.
Laura McenteeInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK.
Nikki FarringtonInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK.
Dhanasekaran ManickamSyngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Narayana ChandrashekaraSyngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Sivakandan JayachandiranSyngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Hrushikesava ReddySyngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Sathya ShankerSyngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India.
Vijay RichardNarayana Health, Mazumdar Shaw Medical Center, 258/A, Bommasandra Industrial Area, Hosur Road, Bangalore, 560 099, India.
Teby ThomasMicrobiology laboratory, St. John's Hospital, Sarjapur Road, Bangalore, 560 034, India.ORCID 0000-0002-3505-977X
Savitha NagarajMicrobiology laboratory, St. John's Hospital, Sarjapur Road, Bangalore, 560 034, India.ORCID 0000-0003-4996-4874
Santanu DattaBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.ORCID 0000-0001-5335-5276
Vasan SambandamurthyBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Vasanthi RamachandranBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.ORCID 0000-0003-2496-179X
Robert ClayHighbury Regulatory Science Limited, SK10 4TG, Nether Alderley, Cheshire, SK10 4TG, UK.ORCID 0000-0002-7085-4752
John TomaykoBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India.
Shampa DasInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK.
Balasubramanian VBugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India. bala@bugworksresearch.com.ORCID 0000-0003-0473-6894
Funding
Department of Biotechnology, Ministry of Science and Technology (DBT) BT/BIPP0803/30/14Wellcome Trust
Abstract
The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens. BWC0977, a Novel Bacterial Topoisomerase Inhibitor (NBTI) selectively inhibits bacterial DNA replication via inhibition of DNA gyrase and topoisomerase IV. BWC0977 exhibited a minimum inhibitory concentration (MIC
Indexed as
Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAdultAnimalsFemaleGram-Negative BacteriaGram-Positive BacteriaHealthy VolunteersHumansMaleMiceMiddle AgedRatsYoung AdultAnti-Bacterial Agents
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.