Evidence map›Paper›PMID 39293964›Full record

ArticleThe Journal of veterinary medical science2024

Role of DNase I in DNA degradation and cell-free DNA generation after acetaminophen-induced hepatic injury.

Shuhei Takada, Shuhei Ogawa, Ryushin Mizuta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuhei TakadaResearch Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Shuhei OgawaResearch Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
Ryushin MizutaResearch Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free DNA (cfDNA), the DNA in the blood circulation, is a useful marker for diagnosing hereditary diseases and tumors. However, the mechanisms underlying the generation of cfDNA are not completely understood. We previously studied DNases [Caspase-activated DNase (CAD), DNase1L3, and DNase I] and reported that in acetaminophen-induced liver necrosis, DNase1L3 was the main endonuclease generating cfDNA, with CAD playing a supporting role. In this study, we generated triple-gene knockout (TKO) mice, Cad

Indexed as

AcetaminophenCell-Free Nucleic AcidsChemical and Drug Induced Liver InjuryDeoxyribonuclease IEndodeoxyribonucleasesMice, KnockoutAnimalsDeoxyribonucleasesMaleMiceMice, Inbred C57BLAcetaminophencaspase-activated deoxyribonucleaseCell-Free Nucleic AcidsDeoxyribonuclease IDeoxyribonucleasesDnase1l3 protein, mouseEndodeoxyribonucleasesacetaminophenCADcell-free DNADNase1L3DNase I

Identifiers

PMID39293964
PMCPMC11569875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.