SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2024
Diagnostic yield and safety of diagnostic techniques for pulmonary lesions: systematic review, meta-analysis and network meta-analysis.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Comparative Study of Electromagnetic Navigation Bronchoscopic With Ultra-thin Cryobiopsy and Forceps Biopsy in the Diagnosis of Peripheral Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Needle Biopsy for the Diagnosis of Peripheral Pulmonary Lesions
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Robotic-assisted transbronchial biopsy versus computed tomography-guided transthoracic needle biopsy for peripheral pulmonary lesions: a systematic review and meta-analysis of direct comparative studies.Journal of robotic surgery · 2026Pooled it
- Accuracy of Deep Learning in Diagnosing Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Innovative technologies and their clinical prospects for early lung cancer screening.Clinical and experimental medicine · 2025Pooled it
- Innovative technologies and their clinical prospects for early lung cancer screening.Clinical and experimental medicine · 2025Pooled it
- Diagnostic performance and safety for robotic-assisted bronchoscopy in pulmonary nodules: a systematic review and meta-analysis.International journal of surgery (London, England) · 2025Pooled it
- Advanced Bronchoscopic Approaches to Peripheral Pulmonary Lesions: a Narrative Review of Current and Emerging Techniques.Pulmonary therapy · 2026Review
- Comparison of diagnostic yield between electromagnetic navigation bronchoscopy-guided forceps biopsy and target-fixing technique-assisted RP-EBUS-guided transbronchial cryobiopsy with a guide sheath for peripheral lung lesions.Translational lung cancer research · 2026Article
- Robotic-assisted bronchoscopy for lung cancer: bibliometric and visualized analysis.Journal of robotic surgery · 2026Review
- Review
- Article
- The addition of radial endobronchial ultrasound to electromagnetic navigation bronchoscopy: the NEBULA study - a randomised controlled trial.ERJ open research · 2026Article
- Application of hand-drawn bronchial navigation and rapid on-site evaluation combined with endobronchial ultrasound for the diagnosis of peripheral lung lesions.The Journal of international medical research · 2026Article
- Application of confocal laser endomicroscopy in the diagnosis of peripheral pulmonary lesions: a narrative review.Journal of thoracic disease · 2026Review
- Predictors of Diagnostic Yield in Shape-Sensing Robotic-Assisted Bronchoscopy (ssRAB): A Retrospective Single-Center Study.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic Yield and Safety of Radial Probe Endobronchial Ultrasound-Guided Transbronchial Lung Cryobiopsy with a Guide Sheath in Pulmonary Lesions < 3 cm.Diagnostics (Basel, Switzerland) · 2026Article
- Determinants of Pneumothorax and Alveolar Hemorrhage After CT-Guided Lung Biopsy.Diagnostics (Basel, Switzerland) · 2026Article
- The Contribution of Radial Endobronchial Ultrasound (EBUS) in the Diagnosis of Pulmonary Cystic Lesions.Cureus · 2026Article
- Establishing a Cone Beam CT-Guided Bronchoscopy Program: A Stepwise Guide for Interventional Pulmonologists.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic Accuracy of Sputum and Bronchoscopy-Guided Cytology Compared With Bronchial Biopsy in Pulmonary Lesions.Cureus · 2026Article
- Comparing the effectiveness and safety of robotic-assisted bronchoscopy and computed tomography-guided transthoracic biopsy for evaluating pulmonary lung nodules: results from the DYSTRICT study.ERJ open research · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith recent advancements in bronchoscopic procedures, data on the best modality to sample peripheral pulmonary lesions (PPLs) is lacking, especially comparing bronchoscopy with computed tomography-guided transthoracic biopsy or needle aspiration (CT-TBNA).
methodsWe performed a meta-analysis, pairwise meta-analysis and network meta-analysis on studies reporting diagnostic yield and complications with the use of CT-TBNA, radial endobronchial ultrasound (rEBUS), virtual bronchoscopy (VB), electromagnetic navigation (EMN) or robot-assisted bronchoscopy (RAB) to sample PPLs. The primary outcome was diagnostic yield and the secondary outcome was complications. We estimated the relative risk ratios using a random-effects model and used the frequentist approach for the network meta-analysis. We performed extensive analysis to assess the heterogeneity including reporting bias, publication bias, subgroup and meta-regressional analysis. We assessed the quality of the studies using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) and QUADAS-Comparative (QUADAS-C).
resultsWe included 363 studies. The overall pooled diagnostic yield was 78.1%, the highest with CT-TBNA (88.9%), followed by RAB (84.8%) and the least with rEBUS (72%). In the pairwise meta-analysis, only rEBUS showed inferiority to CT-TBNA. The network meta-analysis ranked CT-TBNA as likely the most effective approach followed by VB, EMN and RAB, while rEBUS was the least effective, with a low-GRADE certainty. CT-TBNA had the highest rate of complications.
conclusionAlthough CT-TBNA is the most effective approach to sample PPLs, RAB has a comparable diagnostic yield with a lesser complication rate. Further prospective studies are needed comparing CT-TBNA and RAB.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.