ArticleNature2024
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans.FEBS open bio · 2026Article
- GPR15-guided CD8Nature · 2026Article
- Dynamic remodeling of the pancreas immune landscape in obesity.Nature communications · 2026Article
- A Keratinocyte-Mast Cell NF-κB2/CXCL2/IL-6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacological reviews · 2026Review
- Comprehensive analysis of interactions between brain aging and late-onset psychoses using heuristic mapping models.Communications medicine · 2026Article
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Pharmacological proximities in the GPCR family discovered using contact-informed amino-acid and binding pocket similarities.bioRxiv : the preprint server for biology · 2026Article
- Flipping the script: Using mucosal immune obstacles to inform vaccine design.PLoS pathogens · 2026Article
- Association between frailty and the risks of chronic pulmonary diseases and lung cancer.BMC pulmonary medicine · 2026Article
- Dual Roles of MAIT Cells in the Tumor Microenvironment: Implications for Cancer Immunity and Therapy.Immune network · 2026Review
- Identification and functional characterization of two CXCL17 paralogs from zebrafish.The Biochemical journal · 2026Article
- Role of mucosal chemokines in the development of tissue-resident CD4Frontiers in immunology · 2026Review
- GPCRs interaction with LGR5: Implications to cancer stemness.Journal of Cancer · 2026Article
- GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells.Science immunology · 2025Article
- Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes.Developmental cell · 2025Article
- A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma.Nature immunology · 2025Article
- MAIT cell homing in intestinal homeostasis and inflammation.Science advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Borja Ocón *Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. boconmor@stanford.edu.ORCID 0000-0002-5136-7844
Menglan Xiang *Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. mxiang1@stanford.edu.ORCID 0000-0003-4234-4998
Yuhan Bi *Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. yub10@stanford.edu.ORCID 0000-0002-2123-0951
Serena TanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Kevin BruloisDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Aiman AyeshaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0002-7523-5974
Manali KuntePalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Catherine ZhouPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Melissa LaJevicPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Nicole LazarusPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Francesca MengoniDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Tanya SharmaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Stephen MontgomeryDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5200-3903
Jody E HooperDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8209-3559
Mian HuangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Tracy HandelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
John R D DawsonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Irina KufarevaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Brian A ZabelPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Junliang Pan *Palo Alto Veterans Institute for Research, Palo Alto, CA, USA.ORCID 0000-0002-2373-0917
Eugene C ButcherDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8786-7907
Funding
Progenitor Cells for High Endothelium in the Immune ResponseR01AI130471 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI EUGENE C BUTCHER · 2017 to 2026
$5.0MIntestinal Lymphocyte TraffickingR01AI047822 · NIAID · STANFORD UNIVERSITY · PI EUGENE C BUTCHER · 2001 to 2026
$4.7MIt's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12R01AI161880 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M, KUFAREVA, IRINA · 2021 to 2025
$3.4MIdentifying causal genetic variants and molecular mechanisms impacting mental healthR01MH125244 · NIMH · STANFORD UNIVERSITY · PI KUNDAJE, ANSHUL, MONTGOMERY, STEPHEN · 2021 to 2025
$3.0MNovel Lymphocyte Chemoattractant Receptor and LigandR01AI178113 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI EUGENE C BUTCHER · 2024 to 2026
$2.1MSignaling circuits that drive cell movement and ligand scavenging by chemokine receptor CCR2R01GM136202 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M, KUFAREVA, IRINA · 2020 to 2023
$1.9MSpatiotemporally resolved architecture of G protein signaling downstream of CXCR4, the driver of lymphocyte migrationR21AI156662 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUFAREVA, IRINA · 2021 to 2022
$434kComputationally informed discovery of scavenging-sparing inhibitors of CC chemokine receptor 2R21AI149369 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUFAREVA, IRINA · 2020 to 2021
$434kNew Approaches to Combat CNS Inflammation: Targeting a Metabolic Enzyme in Demyelinating DiseaseI01BX004115 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BRIAN A. ZABEL · 2019 to 2026
–BLRD VA I01 BX002919BLRD VA I01 BX004115NIAID NIH HHS R01 AI047822NIAID NIH HHS R01 AI130471NIAID NIH HHS R01 AI161880NIAID NIH HHS R01 AI178113NIAID NIH HHS R21 AI149369NIAID NIH HHS R21 AI156662NIGMS NIH HHS R01 GM136202NIMH NIH HHS R01 MH125244
Abstract
Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon and skin are known
Indexed as
Central Nervous SystemChemokines, CXCLungLymphocytesMucous MembraneReceptors, G-Protein-CoupledAnimalsAutoimmune DiseasesB-LymphocytesChemotaxisEpithelial CellsFemaleHumansImmune ToleranceImmunity, InnateImmunologic MemoryChemokines, CXCCXCL17 protein, humanGPR25 protein, humanReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.