ArticleCell host & microbe2024
Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium.
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Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12citing papers in PubMed, 1 pooled it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Orchestrating life's first community: molecular assembly by human milk oligosaccharides.Gut microbes · 2026Review
- Role of PANoptosis in intestinal diseases and its therapeutic implications.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology.The American journal of pathology · 2026Article
- Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.Frontiers in pediatrics · 2026Review
- Gut microbiota profiling for risk stratification of surgical intervention in preterm infants with necrotizing enterocolitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Chemokine-receptor-dependent inflammatory responses contribute to two-hit-induced experimental necrotizing enterocolitis and represent a potential therapeutic target.Frontiers in immunology · 2026Article
- Autoinflammation with infantile enterocolitis induced by a heterozygous variant (c.1357C > T) in the NLRC4 gene: a case report.Frontiers in pediatrics · 2026Article
- Refining microbiome resolution: KoSCAPEGut microbes · 2025Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Determining the Importance of Carbohydrate-Based Structures in Murine Norovirus Binding to Commensal Bacteria.Viruses · 2025Article
- Elevated DUOX2 levels correlate with necrotizing enterocolitis development.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Saravanan SubramanianPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Hua GengPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Longtao WuDepartment of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA.
Chao DuDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Amy M PeiperDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Heng-Fu BuPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Pauline M ChouDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Xiao WangPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Stephanie C TanDepartment of Medical Education, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA.
Neha R IyerDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Nazeer Hussain KhanPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ellen L ZechnerInstitute of Molecular Biosciences, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Rolf BreinbauerInstitute of Organic Chemistry, Graz University of Technology, 8010 Graz, Austria.
Chao QiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Bakhtiar YaminiDepartment of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA.
Jenny P TingDepartment of Genetics, Department of Microbiology-Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Isabelle G De PlaenDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Stephanie M KarstDepartment of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Xiao-Di TanPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Research & Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA. Electronic address: xtan25@uic.edu.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MBASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3MElucidation of Pathogenic Mechanisms underlying Norovirus DiarrheaR01AI162970 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2021 to 2025
$3.0MSuppression of Enteric Norovirus Infection by Microbiota-Regulated Bile AcidsR01AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2019 to 2023
$2.7MInteractions Between the Microbiota and Helicobacter pylori in Gastric CarcinogenesisR01CA281732 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JAMES G FOX, RICHARD M. PEEK · 2023 to 2026
$2.7MRole of the intestinal microvasculature in necrotizing enterocolitisR01DK116568 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2019 to 2023
$2.7MInsights into a multi-hit process in the development of necrotizing enterocolitisR01DK129960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2022 to 2025
$2.6MMechanisms underlying regulation of intestinal epithelial homeostasis in sepsisR01DK123826 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2020 to 2023
$2.4MThe Role of Norovirus Interactions with the Epithelial Barrier in Acute GastroenteritisF30AI172364 · NIAID · UNIVERSITY OF FLORIDA · PI Amy Marie Peiper · 2023 to 2026
$144kMilk fat globule-EGF factor 8 and hepatocyte apoptosis-induced liver wound healing responseI01BX006085 · VA · JESSE BROWN VA MEDICAL CENTER · PI Xiao-Di Tan · 2023 to 2026
–BLRD VA I01 BX004120BLRD VA I01 BX006085NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA281732NIAID NIH HHS F30 AI172364NIAID NIH HHS R01 AI141478NIAID NIH HHS R01 AI162970NIAID NIH HHS T32 AI007110NIDDK NIH HHS R01 DK116568NIDDK NIH HHS R01 DK123826NIDDK NIH HHS R01 DK129960NIEHS NIH HHS P30 ES027792
Abstract
Microbiota and feeding modes influence the susceptibility of premature newborns to necrotizing enterocolitis (NEC) through mechanisms that remain unknown. Here, we show that microbiota colonization facilitated by breastmilk feeding promotes NOD-like receptor family CARD domain containing 5 (Nlrc5) gene expression in mouse intestinal epithelial cells (IECs). Notably, inducible knockout of the Nlrc5 gene in IECs predisposes neonatal mice to NEC-like injury in the small intestine upon viral inflammation in an NK1.1
Indexed as
Animals, NewbornEnterocolitis, NecrotizingGastrointestinal MicrobiomeIntestinal MucosaSTAT1 Transcription FactorAnimalsEpithelial CellsHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, KnockoutSignal TransductionIntracellular Signaling Peptides and ProteinsStat1 protein, mouseSTAT1 Transcription Factorautoimmunitybreastmilk feeding and formula feedingEarly life microbiota colonizationintestinal epithelial cellsnecrotizing enterocolitisNLRC5PPAR-γSTAT1tilivalline-producing Klebsiella spp.viral inflammation and NK cell cytotoxicity
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