Evidence map›Paper›PMID 39293251›Full record

ArticleSchizophrenia research2024

Retinal electrophysiological alterations are associated with cognition in early course psychosis.

Willa Molho, Brendan Stiltner, Nicolas Raymond, Chelsea Kiely, Rebekah Trotti, Caroline Harris, Deepthi Bannai, Matcheri Keshavan, Steven Silverstein, Paulo Lizano

Abstract read
In one paragraph

Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Willa MolhoDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Brendan StiltnerDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nicolas RaymondDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Chelsea KielyDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Rebekah TrottiDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Caroline HarrisDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Deepthi BannaiDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Matcheri KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Steven SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
Paulo LizanoDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: plizano@bidmc.harvard.edu.

Funding

Retinal Layer, Microvascular and Electroretinographic Determinants of Early Course SchizophreniaK23MH122701 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LIZANO, PAULO L · 2021 to 2024
$768k
A data-driven framework for mapping transcranial electrical stimulation effects on audiovisual integration and hallucinationsF32MH135669 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TROTTI, REBEKAH LYN · 2024 to 2025
$149k
NIMH NIH HHS F32 MH135669NIMH NIH HHS K23 MH122701
6 · The paper itself

Abstract

Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.

Indexed as

ElectroretinographyPsychotic DisordersRetinaAdolescentAdultCognitive DysfunctionFemaleHumansMaleYoung AdultCognitionEarly course psychosisFlash electroretinographyPsychosisRetinography

Identifiers

PMID39293251
PMCPMC12087758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.