Evidence map›Paper›PMID 39292827›Full record

ArticleJournal of proteome research2024

Analysis of Brain Protein Stability Changes in a Mouse Model of Alzheimer's Disease.

Yun Tang, Hye-Jin Park, Shengyu Li, Michael C Fitzgerald

Abstract read
In one paragraph

Article in Journal of proteome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yun TangDepartment of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.ORCID 0000-0002-7479-8268
Hye-Jin ParkDepartment of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.
Shengyu LiDepartment of Computational Biology & Bioinformatics, Duke University, Durham, North Carolina 27708, United States.
Michael C FitzgeraldDepartment of Chemistry, Duke University, Durham, North Carolina 27708-0346, United States.ORCID 0000-0002-6719-4722

Funding

Protein Stability Profiling for the Characterization of Alzheimer's DiseaseR21AG074317 · NIA · DUKE UNIVERSITY · PI FITZGERALD, MICHAEL C · 2022 to 2022
$424k
NIA NIH HHS R21 AG074317
6 · The paper itself

Abstract

The stability of proteins from rates of oxidation (SPROX), thermal proteome profiling (TPP), and limited proteolysis (LiP) techniques were used to profile the stability of ∼2500 proteins in hippocampus tissue cell lysates from 2- and 8-months-old wild-type (C57BL/6J;

Indexed as

Alzheimer DiseaseDisease Models, AnimalMice, Inbred C57BLMice, TransgenicProteasome Endopeptidase ComplexProtein StabilityProteolysisAnimalsBrainHippocampusHumansMiceMutationOxidation-ReductionProtein FoldingProteomeProteasome Endopeptidase ComplexProteomechemical denaturationlimited proteolysismass spectrometryproteasomethermal denaturation

Identifiers

PMID39292827
PMCPMC12129621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.