Evidence map›Paper›PMID 39292673›Full record

ArticlePloS one2024

Prediction of antimicrobial resistance of Klebsiella pneumoniae from genomic data through machine learning.

Chiara Condorelli, Emanuele Nicitra, Nicolò Musso, Dafne Bongiorno, Stefania Stefani, Lucia Valentina Gambuzza, Vincenza Carchiolo, Mattia Frasca

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiara CondorelliDepartment of Electrical Electronic and Computer Science Engineering, University of Catania, Catania, Italy.
Emanuele NicitraDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy.
Nicolò MussoDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy.
Dafne BongiornoDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy.
Stefania StefaniDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy.
Lucia Valentina GambuzzaDepartment of Electrical Electronic and Computer Science Engineering, University of Catania, Catania, Italy.ORCID 0000-0002-5859-285X
Vincenza CarchioloDepartment of Electrical Electronic and Computer Science Engineering, University of Catania, Catania, Italy.
Mattia FrascaDepartment of Electrical Electronic and Computer Science Engineering, University of Catania, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobials, such as antibiotics or antivirals are medications employed to prevent and treat infectious diseases in humans, animals, and plants. Antimicrobial Resistance occurs when bacteria, viruses, and parasites no longer respond to these medicines. This resistance renders antibiotics and other antimicrobial drugs ineffective, making infections challenging or impossible to treat. This escalation in drug resistance heightens the risk of disease spread, severe illness, disability, and mortality. With datasets now containing hundreds or even thousands of pathogen genomes, machine learning techniques are on the rise for predicting antibiotic resistance in pathogens, prediction based on gene content and genome composition. Aim of this work is to combine and incorporate machine learning methods on bacterial genomic data to predict antimicrobial resistance, we will focus on the case of Klebsiella pneumoniae in order to support clinicians in selecting appropriate therapy.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialGenome, BacterialKlebsiella pneumoniaeMachine LearningGenomicsHumansKlebsiella InfectionsAnti-Bacterial Agents

Identifiers

PMID39292673
PMCPMC11410219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.