Evidence map›Paper›PMID 39292340›Full record

ArticleMolecular neurobiology2025

Resveratrol Protects Müller Cells Against Ferroptosis in the Early Stage of Diabetic Retinopathy by Regulating the Nrf2/GPx4/PTGS2 Pathway.

Yi Wang, Si-Yuan Song, Yi Song, Yuan Wang, Zheng-Wei Wan, Ping Sun, Xue-Mei Yu, Bo Deng, Kai-Hong Zeng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi Wang *Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Si-Yuan Song *Baylor College of Medicine, Houston, TX, 77030, USA.
Yi Song *Department of Clinical Nutrition, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Yuan WangDepartment of Clinical Nutrition, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Zheng-Wei WanInstitute of Health Management & Department of Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Ping SunInstitute of Health Management & Department of Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Xue-Mei YuDepartment of Clinical Nutrition, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Bo DengDepartment of Clinical Nutrition, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China. 2725043426@qq.com.
Kai-Hong ZengInstitute of Health Management & Department of Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China. zengkaihong@med.uestc.edu.cn.

Funding

Health and Family Planning Commission Foundation of Sichuan, China 150216Sichuan Provincial Administration of Traditional Chinese Medicine-surface project, China 2021MS470The National Natural Science Foundation of China 81202206
6 · The paper itself

Abstract

The aim of this study was to investigate the anti-ferroptotic effect of resveratrol (RSV) on retinal Müller cells (RMCs) in the early stages of diabetic retinopathy (DR) via the nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPx4)/prostaglandin-endoperoxide synthase 2 (PTGS2). The retina was obtained from normal and diabetic Sprague-Dawley rats or wild-type and Nrf2 knockout (KO) diabetic mice, with or without RSV (10 mg/kg/d) treatment for 12 weeks. RMCs transfected with or without SiNrf2 were cultured with high glucose and RSV (20 mM). The retinal neurofunctional changes were measured by electroretinogram (ERG). The retinal inner nuclear layer cell mitochondrial morphological changes were detected by transmission electron microscopy. The cell viabilities were measured by cell counting kit-8 (CCK-8) assay. The levels of Fe

Indexed as

Cyclooxygenase 2Diabetic RetinopathyEpendymoglial CellsFerroptosisNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseResveratrolSignal TransductionAnimalsCell SurvivalDiabetes Mellitus, ExperimentalMaleMiceMice, KnockoutMitochondriaRatsCyclooxygenase 2NF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseResveratrolDiabetic RetinopathyFerroptosisGlutathione Peroxidase 4Müller CellsNuclear Factor Erythroid 2-related Factor 2Prostaglandin-endoperoxide Synthase 2Resveratrol

Identifiers

PMID39292340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.