Evidence map›Paper›PMID 39292275›Full record

SynthesisEuropean journal of pediatrics2024

Levetiracetam versus carbamazepine monotherapy in the management of pediatric focal epilepsy: A systematic review and meta-analysis of randomized controlled trials.

Jefferson Manoel Borges Martins, Paula Larissa Ferreira Vieira, Giovanni Gosch Berton, Vanessa Karlinski Vizentin, Rafael Dos Santos Borges, Ana Livia Chaves Vieira, Celina Cláudia Israel Sefer, Aurimery Gomes Chermont

Abstract readComparative StudyMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jefferson Manoel Borges MartinsDivision of Medicine, Federal University of Pará, Belém, PA, Brazil.ORCID http://orcid.org/0009-0004-1516-3109
Paula Larissa Ferreira VieiraDivision of Medicine, Federal University of Pará, Belém, PA, Brazil.ORCID http://orcid.org/0009-0008-3738-5860
Giovanni Gosch BertonDepartment of Medicine, School of Medicine, University of Padua, Ospedale Civile St., 77, 35121, Padua, Veneto, Italy. giovanni.goschberton@studenti.unipd.it.ORCID http://orcid.org/0000-0001-6152-2564
Vanessa Karlinski VizentinDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0005-4332-8465
Rafael Dos Santos BorgesDivision of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-1530-6523
Ana Livia Chaves VieiraDivision of Medicine, Federal University of Pará, Belém, PA, Brazil.ORCID http://orcid.org/0009-0005-6804-4135
Celina Cláudia Israel SeferDivision of Medicine, Metropolitan University Center of the Amazon, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-6750-4009
Aurimery Gomes ChermontDivision of Medicine, Federal University of Pará, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-8715-3576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levetiracetam (LEV) and carbamazepine (CBZ) are effective monotherapies for focal epilepsy in children. However, the best drug remains controversial. Therefore, we performed a systematic review and meta-analysis comparing LEV and CBZ monotherapy in the management of pediatric focal epilepsy (PFE). We searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) published until February 2024 comparing LEV and CBZ monotherapy in PFE. Statistical analysis was performed using R version 4.2.2, heterogeneity was assessed using I

Indexed as

AnticonvulsantsCarbamazepineEpilepsies, PartialLevetiracetamChildHumansRandomized Controlled Trials as TopicTreatment OutcomeAnticonvulsantsCarbamazepineLevetiracetamCarbamazepineFocal epilepsyLevetiracetamMonotherapyPediatric

Identifiers

PMID39292275
PMCPMC11473619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.