Evidence map›Paper›PMID 39292226›Full record

Observational studyArchives of gynecology and obstetrics2024

Using Doppler ultrasound to assess fetal cardiac function and pregnancy outcomes in obstetric antiphospholipid syndrome pregnancies: a case-control study.

Bingyan Wang, Qianqian Wang, Dongmei Yu, Nan Zhang, Zhibin Wang, Xinrui Sun, Meixin Liu, Xiaoting Su

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bingyan WangDepartment of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.ORCID 0000-0002-2219-995X
Qianqian WangDepartment of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Dongmei YuDepartment of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Nan ZhangDepartment of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Zhibin WangDepartment of Echocardiography, The Affiliated Hospital of Qingdao University, Shandong, 266003, China.
Xinrui SunDepartment of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Meixin Liu *Department of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China. liumeixin@qduhospital.cn.ORCID 0000-0003-4687-702X
Xiaoting Su *Department of Obstetrical Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China. suxiaoting@qduhospital.cn.ORCID 0000-0003-3274-6467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate fetal left ventricular function (LVF) in pregnant women with obstetric antiphospholipid syndrome (OAPS) by Doppler ultrasound and developed a clinical nomogram to predict adverse perinatal outcomes.

methodsIn this prospective observational study, 105 pregnant women were enrolled and divided into the OAPS cohort (n = 60) and the control cohort (n = 45). Fetal cardiac function parameters were collected and compared between two cohorts. Univariate and multivariate analysis was conducted to select the risk factors associated with adverse perinatal outcomes, and a clinical nomogram was developed based on these selected risk factors. The predictive performance of corresponding indicators for adverse perinatal outcomes was evaluated using receiver operating characteristic (ROC) curve analysis.

resultsThe OAPS cohort revealed an increase in the isovolumic relaxation time (IVRT) and myocardial performance index (MPI), a decrease in the ejection time (ET), middle cerebral artery pulsatility index (MCA-PI) and cerebroplacental ratio (CPR) compared to the control cohort. Through univariate and multivariate analysis, gravidity, CPR, and MPI were the risk factors associated with adverse perinatal outcomes. A model predicting adverse perinatal outcomes in OAPS pregnant women was constructed based on these three factors and visualized as a nomogram. The nomogram could accurately predict adverse perinatal outcomes with an area under the curve of 0.923 (95% CI: 0.858-0.982). This performance was better than evaluating individual factors such as MPI (0.825, 95% CI: 0.739-0.911) and CPR (0.816, 95% CI: 0.705-0.927) for efficacy.

conclusionMPI can be used to assess fetal LVF and predict adverse perinatal outcomes. We developed a nomogram to predict adverse perinatal outcomes in OAPS women. This imaging-based evidence can provide timely clinical intervention, enabling personalized clinical decision-making.

Indexed as

Antiphospholipid SyndromeFetal HeartNomogramsPregnancy OutcomeUltrasonography, PrenatalAdultCase-Control StudiesFemaleHumansPregnancyPregnancy ComplicationsProspective StudiesPulsatile FlowRisk FactorsROC CurveUltrasonography, DopplerFetusLeft cardiac functionMyocardial performance indexNomogram

Identifiers

PMID39292226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.