Evidence map›Paper›PMID 39292205›Full record

ArticleEuropean journal of immunology2024

Reduction in mucosal-associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN-γ concentration.

Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen

Abstract read
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In one paragraph

Article in European journal of immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.The Journal of clinical endocrinology and metabolism · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iivo HetemäkiTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-6576-3549
Joona SarkkinenTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Huai Hui WongImmuDocs National Doctoral Education Pilot Program, University of Helsinki, Helsinki, Finland.
Nelli HeikkiläTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-8879-1569
Saila LaaksoChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Simo MiettinenTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mikko I MäyränpääDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Outi MäkitieChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
T Petteri ArstilaTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eliisa KekäläinenTranslational Immunology Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

EJPRD JTC2019Emil Aaltosen SäätiöHelsinki UniversityHelsinki University Doctoral Programme in BiomedicineHelsinki University HospitalInstrumentariumin TiedesäätiöLastentautien TutkimussäätiöNovo Nordisk FondenResearch Council of Finland 308912Research Council of Finland 308913Sigrid Juséliuksen SäätiöSuomen Lääketieteen Säätiö
6 · The paper itself

Abstract

Mucosal-associated invariant T cells (MAIT) are innate-like lymphocytes enriched in mucosal organs where they contribute to antimicrobial defense. APECED is an inborn error of immunity characterized by immune dysregulation and chronic mucocutaneous candidiasis. Reduction in the frequency of circulating MAITs has been reported in many inborn errors of immunity, but only in a few of them, the functional competence of MAITs has been assessed. Here, we show in a cohort of 24 patients with APECED, that the proportion of circulating MAITs was reduced compared with healthy age and sex-matched controls (1.1% vs. 2.6% of CD3

Indexed as

Interferon-gammaInterleukinsMucosal-Associated Invariant T CellsAdolescentAdultChildChild, PreschoolFemaleHumansInterleukin-18Interleukin-22MaleMiddle AgedPrimary Immunodeficiency DiseasesYoung AdultInterferon-gammaInterleukin-18Interleukin-22InterleukinsAIREAnti‐cytokine antibodiesAPECEDAPS‐1IFN‐γIL‐18Inborn errors of immunityMAIT

Identifiers

PMID39292205
PMCPMC11628920

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.