Evidence map›Paper›PMID 39291998›Full record

ArticleAntimicrobial agents and chemotherapy2024

Serum ganciclovir drug exposure in children receiving standard ganciclovir dosing.

Wenyu Yang, Adam Irwin, Heather Weerdenburg, Brett McWhinney, Theresa Cole, Alice Lei, Bing Han, Xiao Zhu, Amanda Gwee

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ganciclovir Therapeutic Drug Monitoring in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyu YangMinhang Hospital & School of Pharmacy, Fudan University, Shanghai, China.ORCID 0000-0002-9057-4520
Adam IrwinCentre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
Heather WeerdenburgChildren's Cancer Centre, Royal Children's Hospital, Melbourne, Victoria, Australia.
Brett McWhinneyDepartment of Chemical Pathology, Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Theresa ColeDepartment of Haematology, Royal Children's Hospital, Melbourne, Melbourne, Victoria, Australia.
Alice LeiDepartment of General Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.
Bing HanDepartment of Pharmacy, Minhang Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-6623-3523
Xiao ZhuMinhang Hospital & School of Pharmacy, Fudan University, Shanghai, China.ORCID 0000-0003-3295-619X
Amanda GweeDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.

Funding

Fudan University Scientific Research Foundation for Talented Scholars JIF301052MOST | National Natural Science Foundation of China (NSFC) 82204544NHMRC Investigator Grant GNT1194694Shanghai Municipal Health Commission Clinical Research Youth Project 20224Y0121
6 · The paper itself

Abstract

Intravenous ganciclovir (GCV) is used for the treatment of cytomegalovirus (CMV) infection in immunocompromised children. Although the therapeutic target for treatment is unclear, studies have shown a serum area under the concentration-time curve (AUC

Indexed as

Antiviral AgentsCytomegalovirus InfectionsGanciclovirAdolescentArea Under CurveChildChild, PreschoolDrug MonitoringFemaleHumansImmunocompromised HostInfantMaleMonte Carlo MethodRetrospective StudiesAntiviral AgentsGanciclovirexternal validationganciclovirmodel-informed precision dosingpediatricspopulation pharmacokinetics

Identifiers

PMID39291998
PMCPMC11459965

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.