Evidence map›Paper›PMID 39291964›Full record

ArticleVeterinary pathology2025

Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia.

Anna M Meredith, Janet Beeler-Marfisi, Olaf Berke, Anthony J Mutsaers, Dorothee Bienzle

Abstract read
In one paragraph

Article in Veterinary pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna M MeredithUniversity of Guelph, Guelph, ON, Canada.ORCID 0000-0001-7094-3424
Janet Beeler-MarfisiUniversity of Guelph, Guelph, ON, Canada.ORCID 0000-0002-4324-1600
Olaf BerkeUniversity of Guelph, Guelph, ON, Canada.ORCID 0000-0003-3537-0629
Anthony J MutsaersUniversity of Guelph, Guelph, ON, Canada.
Dorothee BienzleUniversity of Guelph, Guelph, ON, Canada.ORCID 0000-0002-2301-2931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are heterogeneous neoplasms of hematopoietic stem cells that are challenging to diagnose, differentiate, and prognosticate. Cytogenetic and mutational analyses are useful in humans but unavailable for dogs, where diagnosis and classification still rely largely on hematologic and morphologic assessment. The objectives of this study were to apply a classification scheme to myeloid neoplasms and to assess outcome in relation to predictor variables. Keyword search of a laboratory database, application of sequential exclusion criteria, and consensus from 3 reviewers yielded 70 cases of myeloid neoplasia with hematology results, and cytologic (11), histologic (14), or both (45) types of marrow specimens. Based on blast percentage and morphology, 42 cases were classified as MDS and 28 as AML. Dogs with MDS had significantly lower body weights, hemoglobin concentrations and blood blasts, and higher red blood cell size variability and platelet numbers than dogs with AML. Estimates of median survival using Kaplan-Meier curves for dogs with MDS and AML were 384 and 6 days, respectively (

Indexed as

Bone MarrowDog DiseasesLeukemia, Myeloid, AcuteMyelodysplastic SyndromesAnimalsDogsFemaleKaplan-Meier EstimateMalePrognosisRisk Factorscaninecytopeniadysplasialeukemia classificationmyeloid neoplasiamyeloproliferative disease

Identifiers

PMID39291964
PMCPMC11697499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.