Evidence map›Paper›PMID 39291955›Full record

ArticleProtein science : a publication of the Protein Society2024

Mesoscale explorer: Visual exploration of large-scale molecular models.

Alexander Rose, David Sehnal, David S Goodsell, Ludovic Autin

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes.Protein science : a publication of the Protein Society · 2026
    Article
  3. Molecular architecture of Influenza A virions.bioRxiv : the preprint server for biology · 2026
    Article
  4. Mol* web molecular graphics engine.Protein science : a publication of the Protein Society · 2026
    Article
  5. MolViewStories: Interactive molecular storytelling.Protein science : a publication of the Protein Society · 2026
    Article
  6. Article
  7. Article
  8. Mesoscale explorer: Visual exploration of large-scale molecular models.Protein science : a publication of the Protein Society · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alexander RoseIndependent, San Diego, California, USA.
David SehnalNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.
David S GoodsellDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0002-5932-2130
Ludovic AutinDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0002-2197-191X

Funding

Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Stefan G Sarafianos, Bruce Edward Torbett · 2022 to 2026
$36.7M
Modeling and Interacting with the Visible Molecular CellR01GM120604 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI AUTIN, LUDOVIC · 2016 to 2025
$4.2M
Czech Science Foundation 22-30571MNIAID NIH HHS U54 AI170855NIGMS NIH HHS R01 GM120604NIH HHS 5U54AI170855NIH HHS GM120604
6 · The paper itself

Abstract

The advent of cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET), coupled with computational modeling, has enabled the creation of integrative 3D models of viruses, bacteria, and cellular organelles. These models, composed of thousands of macromolecules and billions of atoms, have historically posed significant challenges for manipulation and visualization without specialized molecular graphics tools and hardware. With the recent advancements in GPU rendering power and web browser capabilities, it is now feasible to render interactively large molecular scenes directly on the web. In this work, we introduce Mesoscale Explorer, a web application built using the Mol* framework, dedicated to the visualization of large-scale molecular models ranging from viruses to cell organelles. Mesoscale Explorer provides unprecedented access and insight into the molecular fabric of life, enhancing perception, streamlining exploration, and simplifying visualization of diverse data types, showcasing the intricate details of these models with unparalleled clarity.

Indexed as

Cryoelectron MicroscopyModels, MolecularSoftwareViruses3D animationinteractive toursmesoscale modelsmolecular graphismweb‐based 3D visualization

Identifiers

PMID39291955
PMCPMC11409463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.