Evidence map›Paper›PMID 39291871›Full record

ArticleLab on a chip2024

Integrated microfluidic multiple electrode aggregometry for point-of-care platelet function analysis.

X Zhao, V R Gopal, F Lozano-Juan, K Kolandaivelu, A Sarkar, D Wu, J Su, Q Cheng, R Pang, L-S Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

X ZhaoState Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China. xinzhao@sjtu.edu.cn.ORCID 0000-0002-0372-638X
V R GopalAtantares Corp, One Broadway, Cambridge, MA, USA.
F Lozano-JuanAtantares Corp, One Broadway, Cambridge, MA, USA.ORCID 0000-0002-0151-2329
K KolandaiveluInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
A SarkarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-9327-1525
D WuAtantares Corp, One Broadway, Cambridge, MA, USA.
J SuAtantares Corp, One Broadway, Cambridge, MA, USA.
Q ChengState Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China. xinzhao@sjtu.edu.cn.
R PangState Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China. xinzhao@sjtu.edu.cn.
L-S WuState Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China. xinzhao@sjtu.edu.cn.

Funding

Miniaturized Global Coagulation Assay System in Neonatal and Pediatric SettingsR43HL140686 · NHLBI · ATANTARES CORPORATION · PI KOLANDAIVELU, KUMARAN, ZHAO, XIN · 2018 to 2018
$150k
NHLBI NIH HHS R43 HL140686
6 · The paper itself

Abstract

Point-of-care (POC) platelet function analysis can enable timely and precise management of bleeding and clotting in emergency rooms, operation rooms and intensive care units. However, POC platelet testing is currently not commonly performed, due to the complexity of sample preparation and limitations of existing technologies. Here, we report the development of an integrated microfluidic multiple electrode aggregometry (μMEA) sensor which uses multi-frequency impedance measurement of an embedded microelectrode array to perform platelet aggregometry directly from whole blood, sensing and measuring platelet activation in a label-free manner and without requiring any additional sample preparation. Additionally, the sensor incorporates blood flow during the assay to account for physiological flow and shear conditions. We show that the impedance signal from the sensor can be used to accurately detect and quantify platelet aggregation in a label-free manner, which was further validated by simultaneous fluorometric measurement and visualization of platelet aggregation. Further, we optimized the sensitivity and repeatability of the sensor using its frequency response and demonstrated that the sensor could be used to characterize drug dose-response in antiplatelet therapy with a frequency-tunable dynamic range. We also demonstrate that the sensor provides high sensitivity to perform platelet aggregometry under thrombocytopenic or low platelet count conditions. The μMEA sensor could thus enable POC platelet function analysis across several clinical applications.

Indexed as

Microfluidic Analytical TechniquesPlatelet AggregationPlatelet Function TestsPoint-of-Care SystemsBlood PlateletsElectrodesEquipment DesignHumansLab-On-A-Chip DevicesMicroelectrodesPlatelet Aggregation InhibitorsPlatelet Aggregation Inhibitors

Identifiers

PMID39291871
PMCPMC11503524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.