Evidence map›Paper›PMID 39291743›Full record

ArticleAnalytical chemistry2024

Label-Free Raman Spectroscopy for Assessing Purity and Maturation of hiPSC-Derived Cardiac Tissue.

Junjun Li, Menglu Li, Yasunori Nawa, Yuting Liu, Kazuki Bando, Ying Hua, Lifu Sun, Satoshi Fujita, Yoshiki Sawa, Katsumasa Fujita and 1 more

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In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junjun LiLaboratory of Nanophotonics, Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-7473-4918
Menglu LiLaboratory of Nanophotonics, Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-2223-1881
Yasunori NawaLaboratory of Nanophotonics, Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.
Yuting LiuDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Suita 565-0871, Japan.
Kazuki BandoAdvanced Photonics and Biosensing Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Suita, Osaka 565-0871, Japan.
Ying HuaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Suita 565-0871, Japan.
Lifu SunDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Suita 565-0871, Japan.
Satoshi FujitaAdvanced Photonics and Biosensing Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Suita, Osaka 565-0871, Japan.
Yoshiki SawaDepartment of Cardiovascular Surgery, Osaka Police Hospital, Osaka 543-0035, Japan.
Katsumasa FujitaLaboratory of Nanophotonics, Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-2284-375X
Li LiuLaboratory of Nanophotonics, Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

I.

backgroundHuman induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs) have been utilized in drug toxicity evaluation, drug discovery, and treating heart failure patients, showing substantial effects. Ensuring the quality, purity, and maturation of hiPSC-CMs during large-scale production is crucial. There is a growing demand for a novel method to characterize cell molecular profiles without labels and without causing damage. II.

methodsIn this study, we employed label-free Raman microscopy to evaluate hiPSC-derived CMs. The study involved the characterization of cell molecular profiles without labels and without causing damage. The correlation between Raman spectroscopy of specific components, such as cytochrome

resultsRaman spectroscopy indicated that the cytochrome

conclusionsWe discovered that Raman spectroscopy of certain components, such as cytochrome

Indexed as

Cell DifferentiationInduced Pluripotent Stem CellsMyocytes, CardiacSpectrum Analysis, RamanCells, CulturedCytochromes cHumansMyoglobinCytochromes cMyoglobin

Identifiers

PMID39291743
PMCPMC11447663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.