Evidence map›Paper›PMID 39291487›Full record

Trial reportJournal of the American Heart Association2024

Atrial Fibrillation Status and Physical Rehabilitation in Older Patients With Acute Decompensated Heart Failure: An Analysis From the REHAB-HF Trial.

Douglas R Corsi, Sean Dikdan, Naman Upadhyay, Haiying Chen, Dalane W Kitzman, Robert Mentz, David J Whellan, Daniel R Frisch

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02196038 (REHAB-HF), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02196038 nacompletednot on this map

REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients

TypeinterventionalSponsorWake Forest University Health SciencesRan2014 to 2020Enrolled349ConditionsAcute Decompensated Heart FailureArmsmulti-domain rehabilitation intervention, Attention Control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Douglas R CorsiDepartment of Medicine Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia PA.ORCID 0000-0001-5133-0235
Sean DikdanDepartment of Electrophysiology Temple University Hospital Philadelphia PA.ORCID 0000-0002-3107-5406
Naman UpadhyayDepartment of Medicine Rutgers Robert Wood Johnson Medical School New Brunswick NJ.ORCID 0000-0001-6767-0488
Haiying ChenDepartment of Biostatistics and Data Science Wake Forest School of Medicine Winston-Salem NC.ORCID 0000-0002-9712-5963
Dalane W KitzmanSection on Cardiovascular Medicine, Department of Internal Medicine Wake Forest School of Medicine Winston-Salem NC.ORCID 0009-0000-5274-0826
Robert MentzDuke University School of Medicine Durham NC.ORCID 0000-0002-3222-1719
David J WhellanDepartment of Medicine Rutgers Robert Wood Johnson Medical School New Brunswick NJ.ORCID 0000-0002-6287-8690
Daniel R FrischDepartment of Medicine Rutgers Robert Wood Johnson Medical School New Brunswick NJ.ORCID 0000-0002-7645-6405

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF TrialR01AG078153 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2022 to 2025
$26.6M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Pepper OAIC Coordinating CenterU24AG059624 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2018 to 2026
$6.0M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Wake Forest Atrium HeartShare Clinical CenterU01HL160272 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2021 to 2026
$2.3M
Repurposing of Metormin for Older Patients with HFpEFU01AG076928 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W, YADAV, HARIOM · 2022 to 2024
$2.3M
NHLBI NIH HHS U01 HL160272NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NIA NIH HHS R01 AG078153NIA NIH HHS U01 AG076928NIA NIH HHS U24 AG059624
6 · The paper itself

Abstract

backgroundThe REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial demonstrated that a transitional, tailored, progressive rehabilitation intervention improved physical function, 6-minute walk distance, frailty, quality-of-life, and depression in older patients hospitalized for acute decompensated heart failure. This analysis assessed the impact of atrial fibrillation (AF) on intervention benefits. METHODS AND

resultsOf 349 enrolled patients hospitalized for acute decompensated heart failure (mean age 72.7±8.1 years), 176 (50.4%) had AF. Participants were randomly assigned to 12-week rehabilitation intervention or attention control. The primary outcome was Short Physical Performance Battery score at 3 months. Participants with AF were older (74.4±8.3 versus 70.8±7.5,

conclusionsIn older, hospitalized patients with acute decompensated heart failure, the presence of AF did not significantly affect the benefit of the rehabilitation intervention on physical function and quality of life. The intervention appears safe and effective regardless of AF status. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT02196038.

Indexed as

Atrial FibrillationCardiac RehabilitationHeart FailureQuality of LifeAcute DiseaseAgedAged, 80 and overExercise TherapyExercise ToleranceFemaleFunctional StatusHumansMaleRecovery of FunctionTime FactorsTreatment Outcomearrhythmiaatrial fibrillationfrailtyheart failurerehabilitation intervention

Identifiers

PMID39291487
PMCPMC11681436

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.