Evidence map›Paper›PMID 39291439›Full record

ArticleJournal of cosmetic dermatology2025

Troxerutin Delays Skin Keratinocyte Senescence Induced by Ionizing Radiation Both In Vitro and In Vivo.

Juping Chen, Jinghui Yang, Jiang Ma, Xiaoming Sun, Yuxuan Wang, Changjiao Luan, Jiaxiao Chen, Weili Liu, Qing Shan, Xingjie Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juping ChenDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.ORCID https://orcid.org/0000-0001-9302-4842
Jinghui YangDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Jiang MaDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xiaoming SunDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Yuxuan WangDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Changjiao LuanDepartment of Lung, The Third People's Hospital of Yangzhou, Yangzhou, China.
Jiaxiao ChenDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Weili LiuDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Qing ShanDepartment of Geriatrics, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Xingjie MaDepartment of the Central Laboratory, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.ORCID https://orcid.org/0000-0003-3528-5854

Funding

the National Natural Science Foundation of China 32000509the Social Development Project of Yangzhou Science and Technology Bureau YZ2020072
6 · The paper itself

Abstract

backgroundsWith the increasing demand for beauty and a healthy lifespan, studies regarding anti-skin aging have drawn much more attention than ever before. Skin cellular senescence, the primary cause of skin aging, is characterized by a cell cycle arrest in proliferating cells along with a senescence-associated secretory phenotype (SASP), which can be triggered by various internal or external stimuli.

aimsRecent studies have made significant progress in the fields of anti-senescence and anti-aging. However, little is known about the roles and functions of natural compounds, particularly flavonoids, in skin cellular senescence studies.

methodsIn this study, using strategies including ionizing radiation (IR), senescence-associated β galactosidase assay (SA-β-Gal), immunofluorescence (IF), flow cytometry, PCR array, as well as in vivo experiments, we investigated the effects and roles of troxerutin (Trx), a natural flavonoid, in skin keratinocyte senescence.

resultsWe found that Trx delays skin keratinocyte senescence induced by IR. Mechanistically, Trx protects the skin keratinocyte cells from senescence by alleviating reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and DNA damage caused by IR. In addition, Trx was also proved to relieve skin senescence and SASP secretion in vivo induced by IR stimulation.

conclusionsAltogether, our findings pointed to a new function of Trx in delaying stress-induced skin keratinocyte senescence, and should thus provide theoretical foundations for exploring novel strategies against skin aging.

Indexed as

Cellular SenescenceHydroxyethylrutosideKeratinocytesSkin AgingAnimalsCells, CulturedDNA DamageHumansMiceRadiation, IonizingReactive Oxygen SpeciesSenescence-Associated Secretory PhenotypeSkinHydroxyethylrutosideReactive Oxygen Speciestroxerutinageaging skincell signalingDNA damagekeratinocytemitochondria dysfunctionskin cellular senescenceTrx

Identifiers

PMID39291439
PMCPMC11743059

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.